Increased phosphorylation of collapsin response mediator protein-2 at Thr514 correlates with ß-amyloid burden and synaptic deficits in Lewy body dementias.

Xing, Huayang; Lim, Yun-An; Chong, Joyce R; Lee, Jasinda H; Aarsland, Dag; Ballard, Clive G; Francis, Paul T; Chen, Christopher P; Lai, Mitchell K P

Xing, Huayang; Lim, Yun-An; Chong, Joyce R; Lee, Jasinda H; Aarsland, Dag; Ballard, Clive G; Francis, Paul T; Chen, Christopher P; Lai, Mitchell K P.

Afiliación

Xing H; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine (MD6), 14 Medical Drive, Kent Ridge, 117599, Singapore.
Lim YA; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine (MD6), 14 Medical Drive, Kent Ridge, 117599, Singapore.
Chong JR; Memory, Ageing and Cognition Centre, National University Health System, Kent Ridge, Singapore.
Lee JH; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine (MD6), 14 Medical Drive, Kent Ridge, 117599, Singapore.
Aarsland D; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Unit 09-01, Centre for Translational Medicine (MD6), 14 Medical Drive, Kent Ridge, 117599, Singapore.
Ballard CG; Department of Neurobiology, Care Sciences and Society, Alzheimer's Disease Research Centre, Karolinska Institutet, Novum, Stockholm, Sweden.
Francis PT; Center for Age-Related Diseases, Stavanger University Hospital, Stavanger, Norway.
Chen CP; King's College London, Wolfson Centre for Age-Related Diseases, London, UK.
Lai MK; King's College London, Wolfson Centre for Age-Related Diseases, London, UK.

Mol Brain ; 9(1): 84, 2016 09 08.

Article en En | MEDLINE | ID: mdl-27609071

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Péptidos y Proteínas de Señalización Intercelular/metabolismo; Enfermedad por Cuerpos de Lewy/metabolismo; Enfermedad por Cuerpos de Lewy/patología; Proteínas del Tejido Nervioso/metabolismo; Fosfotreonina/metabolismo; Sinapsis/metabolismo; Sinapsis/patología; Anciano de 80 o más Años; Estudios de Casos y Controles; Estudios de Cohortes; Quinasa 5 Dependiente de la Ciclina/metabolismo; Citosol/metabolismo; Demografía; Femenino; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Humanos; Masculino; Neocórtex/metabolismo; Neocórtex/patología; Fosforilación; Cambios Post Mortem; Sinaptofisina/metabolismo; Tubulina (Proteína)/metabolismo

Palabras clave

Axonal pathology; Collapsin response mediator protein-2; Dementia with Lewy bodies; Parkinson's disease dementia

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfotreonina / Sinapsis / Péptidos beta-Amiloides / Enfermedad por Cuerpos de Lewy / Péptidos y Proteínas de Señalización Intercelular / Proteínas del Tejido Nervioso Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged80 / Female / Humans / Male Idioma: En Revista: Mol Brain Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 2016 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Reino Unido

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