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Bone mineral density is reduced by telmisartan in male spontaneously hypertensive rats.
Birocale, Antonio Marcos; Medeiros, Ana Raquel Santos; Ruffoni, Leandro Dias Gonçalves; Takayama, Liliam; de Oliveira, José Martins; Nonaka, Keico Okino; Pereira, Rosa Maria Rodrigues; Bissoli, Nazaré Souza.
Afiliación
  • Birocale AM; Department of Health Integrated Education, Federal University of Espirito Santo,Vitória, Brazil. Electronic address: mbirocale@hotmail.com.
  • Medeiros AR; Biological and Health Sciences, Federal Institute of Espirito Santo, Vitória, Brazil.
  • Ruffoni LD; Department of Physiological Sciences, Federal University of São Carlos, São Carlos, Brazil.
  • Takayama L; Department of Medical Clinic, Medicine College, University of São Paulo, São Paulo, Brazil.
  • de Oliveira JM; Laboratory of Applied Nuclear Physics, University of Sorocaba, Sorocaba, Brazil.
  • Nonaka KO; Department of Physiological Sciences, Federal University of São Carlos, São Carlos, Brazil.
  • Pereira RM; Department of Medical Clinic, Medicine College, University of São Paulo, São Paulo, Brazil.
  • Bissoli NS; Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, Brazil.
Pharmacol Rep ; 68(6): 1149-1153, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27607362
BACKGROUND: Telmisartan, an angiotensin AT1 receptor blocker, and treadmill running were compared for their effects on bone mineral density (BMD) and biomechanical properties of male spontaneously hypertensive rats (SHR). It was hypothesized that running (18m/min/60min/d) and telmisartan (5mg/kg/d) would have a positive effect on bone parameters. METHODS: Three-month-old male SHRs were divided into three groups: sedentary (S), telmisartan (T), and exercise (E). At the end of an 8-week protocol, femur and lumbar vertebrae were analyzed by dual-energy X-ray absorptiometry (DXA) for bone mineral density and by the three-point bending test for biomechanical properties. Blood pressure in all groups was measured by a tail-cuff manometer. RESULTS: Telmisartan and treadmill running reduced blood pressure when compared to the sedentary group; however, telmisartan did not improve bone characteristics. Instead, it reduced BMD of femur total and lumbar vertebrae and worsened bone biomechanic properties. Treadmill running maintained bone characteristics and hence was effective in maintaining bone health. CONCLUSION: Results showed that telmisartan negatively affected bones suggesting that caution should be taken in possible therapeutic applications for protecting bone health in hypertensive conditions. More studies are necessary to clarify the mechanisms through which telmisartan favors bone loss in this model.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Bencimidazoles / Benzoatos / Densidad Ósea / Bloqueadores del Receptor Tipo 1 de Angiotensina II / Prueba de Esfuerzo / Hipertensión Tipo de estudio: Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Bencimidazoles / Benzoatos / Densidad Ósea / Bloqueadores del Receptor Tipo 1 de Angiotensina II / Prueba de Esfuerzo / Hipertensión Tipo de estudio: Guideline / Prognostic_studies Límite: Animals Idioma: En Revista: Pharmacol Rep Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Suiza