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Mild hypothermia protects against early brain injury in rats following subarachnoid hemorrhage via the TrkB/ERK/CREB signaling pathway.
Lv, Ou; Zhou, Fenggang; Zheng, Yongri; Li, Qingsong; Wang, Jianjiao; Zhu, Yulan.
Afiliación
  • Lv O; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  • Zhou F; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  • Zheng Y; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  • Li Q; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  • Wang J; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
  • Zhu Y; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.
Mol Med Rep ; 14(4): 3901-7, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27600366
Subarachnoid hemorrhage (SAH) is a severe neurological disease, which is associated with a significant number of cases of premature mortality and disability worldwide. Mild hypothermia (MH) has been proposed as a potential therapeutic strategy to reduce neuronal injury following SAH. The present study aimed to investigate the mechanisms of MH's protective role in the process of SAH. The present study demonstrated that MH was able to protect against early brain injury in a rat model of SAH. Treating SAH rats with MH reduced the release of reactive oxygen species and prevented activation of apoptotic cascades. Furthermore, the protective effects of MH were shown to be mediated by enhanced activity of the tropomyosin receptor kinase B/extracellular signal­regulated kinases/cAMP response element binding protein (TrkB/ERK/CREB) pathway. Inhibition of TrkB/ERK/CREB activity using a small molecule inhibitor largely abolished the beneficial effects of MH in SAH rats. These results outline an endogenous mechanism underlying the neuroprotective effects of MH in SAH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Subaracnoidea / Lesiones Encefálicas / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Receptor trkB / Quinasas MAP Reguladas por Señal Extracelular / Hipotermia Inducida Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2016 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Subaracnoidea / Lesiones Encefálicas / Proteína de Unión a Elemento de Respuesta al AMP Cíclico / Receptor trkB / Quinasas MAP Reguladas por Señal Extracelular / Hipotermia Inducida Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2016 Tipo del documento: Article Pais de publicación: Grecia