Your browser doesn't support javascript.
loading
Changes in Urinary Microbiome Populations Correlate in Kidney Transplants With Interstitial Fibrosis and Tubular Atrophy Documented in Early Surveillance Biopsies.
Modena, B D; Milam, R; Harrison, F; Cheeseman, J A; Abecassis, M M; Friedewald, J J; Kirk, A D; Salomon, D R.
Afiliación
  • Modena BD; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
  • Milam R; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
  • Harrison F; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
  • Cheeseman JA; Department of Surgery, Duke University, Durham, NC.
  • Abecassis MM; Northwestern Comprehensive Transplant Center, Northwestern University, Chicago, IL.
  • Friedewald JJ; Northwestern Comprehensive Transplant Center, Northwestern University, Chicago, IL.
  • Kirk AD; Department of Surgery, Duke University, Durham, NC.
  • Salomon DR; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Am J Transplant ; 17(3): 712-723, 2017 03.
Article en En | MEDLINE | ID: mdl-27597148
An unbalanced microbiome may lead to disease by creating aberrant immune responses. A recent association of cellular rejection with the development of interstitial fibrosis and tubular atrophy (IFTA) suggests the role of immune-mediated tissue injury. We hypothesized that developing IFTA correlates with altered urinary tract microbiomes (UMBs). UMBs at two serial time points, 1 and 6-8 months posttransplant, were assessed by 16S microbial ribosomal gene sequencing in 25 patients developing biopsy-proven IFTA compared to 23 transplant patients with normal biopsies and excellent function (TX) and 20 healthy nontransplant controls (HC). Streptococcus, the dominant genera in HC males, was lower in IFTA and TX males at 1 month compared to HCs. At 6-8 months, Streptococcus was further decreased in IFTA males, but normalized in TX. IFTA males and females had increases in number of genera per sample at 6-8 months. UMB composition varied substantially between individuals in all groups. Despite the wide variation in UMBs between individuals, IFTA was associated with a loss in dominant resident urinary microbes in males, and a parallel increase in nonresident, pathogenic bacteria in males and females. UMB changes may contribute to IFTA development by alteration of the host immune response.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrofia / Fibrosis / Biomarcadores / Trasplante de Riñón / Enfermedades Pulmonares Intersticiales / Microbiota / Rechazo de Injerto / Túbulos Renales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atrofia / Fibrosis / Biomarcadores / Trasplante de Riñón / Enfermedades Pulmonares Intersticiales / Microbiota / Rechazo de Injerto / Túbulos Renales Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos