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Voltage-Gated Sodium Channels: Evolutionary History and Distinctive Sequence Features.
Kasimova, M A; Granata, D; Carnevale, V.
Afiliación
  • Kasimova MA; Temple University, Philadelphia, PA, United States.
  • Granata D; Temple University, Philadelphia, PA, United States.
  • Carnevale V; Temple University, Philadelphia, PA, United States.
Curr Top Membr ; 78: 261-86, 2016.
Article en En | MEDLINE | ID: mdl-27586287
Voltage-gated sodium channels (Nav) are responsible for the rising phase of the action potential. Their role in electrical signal transmission is so relevant that their emergence is believed to be one of the crucial factors enabling development of nervous system. The presence of voltage-gated sodium-selective channels in bacteria (BacNav) has raised questions concerning the evolutionary history of the ones in animals. Here we review some of the milestones in the field of Nav phylogenetic analysis and discuss some of the most important sequence features that distinguish these channels from voltage-gated potassium channels and transient receptor potential channels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evolución Molecular / Canales de Sodio Activados por Voltaje Límite: Animals Idioma: En Revista: Curr Top Membr Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evolución Molecular / Canales de Sodio Activados por Voltaje Límite: Animals Idioma: En Revista: Curr Top Membr Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos