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Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort.
Matta, Joane; Carette, Claire; Levy Marchal, Claire; Bertrand, Julien; Pétéra, Mélanie; Zins, Marie; Pujos-Guillot, Estelle; Comte, Blandine; Czernichow, Sébastien.
Afiliación
  • Matta J; INSERM, UMS 011, Villejuif, France.
  • Carette C; Nutrition Department, Hôpital Européen Georges-Pompidou, Paris, France.
  • Levy Marchal C; INSERM CIE 05 - Unité d'épidémiologie clinique, Hôpital Robert Debré, Paris, France.
  • Bertrand J; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
  • Pétéra M; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
  • Zins M; INSERM, UMS 011, Villejuif, France Paris Descartes University, Paris, France.
  • Pujos-Guillot E; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
  • Comte B; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France.
  • Czernichow S; INSERM, UMS 011, Villejuif, France Nutrition Department, Hôpital Européen Georges-Pompidou, Paris, France Paris Descartes University, Paris, France.
BMJ Open ; 6(8): e011367, 2016 08 31.
Article en En | MEDLINE | ID: mdl-27580829
BACKGROUND: An obesity subphenotype, named 'metabolically healthy obese' (MHO) has been recently defined to characterise a subgroup of obese individuals with less risk for cardiometabolic abnormalities. To date no data are available on participants born with small weight for gestational age (SGA) and the risk of metabolically unhealthy obesity (MUHO). OBJECTIVE: Assess the risk of MUHO in SGA versus appropriate for gestational age (AGA) adult participants. METHODS: 129 young obese individuals (body mass index ≥30 kg/m²) from data of an 8-year follow-up Haguenau cohort (France), were identified out of 1308 participants and were divided into 2 groups: SGA (n=72) and AGA (n=57). Metabolic characteristics were analysed and compared using unpaired t-test. The HOMA-IR index was determined for the population and divided into quartiles. Obese participants within the first 3 quartiles were considered as MHO and those in the fourth quartile as MUHO. Relative risks (RRs) and 95% CI for being MUHO in SGA versus AGA participants were computed. RESULTS: The SGA-obese group had a higher risk of MUHO versus the AGA-obese group: RR=1.27 (95% CI 1.10 to 1.6) independently of age and sex. CONCLUSIONS: In case of obesity, SGA might confer a higher risk of MUHO compared with AGA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso Corporal / Recién Nacido Pequeño para la Edad Gestacional / Obesidad Metabólica Benigna Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso Corporal / Recién Nacido Pequeño para la Edad Gestacional / Obesidad Metabólica Benigna Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: BMJ Open Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido