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Genome-wide association study for milk somatic cell score in holstein cattle using copy number variation as markers.
Durán Aguilar, M; Román Ponce, S I; Ruiz López, F J; González Padilla, E; Vásquez Peláez, C G; Bagnato, A; Strillacci, M G.
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  • Durán Aguilar M; Facultad de Estudios Superiores Cuautitlán, UNAM, Cuautitlán Izcalli, México.
  • Román Ponce SI; Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, INIFAP, Auchitlán, Querétaro, México.
  • Ruiz López FJ; Centro Nacional de Investigación en Fisiología y Mejoramiento Animal, INIFAP, Auchitlán, Querétaro, México.
  • González Padilla E; Departamento de Genética y Bioestadística, Facultad Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México DF, México.
  • Vásquez Peláez CG; Departamento de Genética y Bioestadística, Facultad Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México DF, México.
  • Bagnato A; Department of Veterinary Medicine (DiMeVet), University of Milan, Milan, Italy.
  • Strillacci MG; Department of Veterinary Medicine (DiMeVet), University of Milan, Milan, Italy.
J Anim Breed Genet ; 134(1): 49-59, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27578198
Mastitis, the most common and expensive disease in dairy cows, implies significant losses in the dairy industry worldwide. Many efforts have been made to improve genetic mastitis resistance in dairy populations, but low heritability of this trait made this process not as effective as desired. The purpose of this study was to identify genomic regions explaining genetic variation of somatic cell count using copy number variations (CNVs) as markers in the Holstein population, genotyped with the Illumina BovineHD BeadChip. We found 24 and 47 copy number variation regions significantly associated with estimated breeding values for somatic cell score (SCS_EBVs) using SVS 8.3.1 and PennCNV-CNVRuler software, respectively. The association analysis performed with these two software allowed the identification of 18 candidate genes (TERT, NOTCH1, SLC6A3, CLPTM1L, PPARα, BCL-2, ABO, VAV2, CACNA1S, TRAF2, RELA, ELF3, DBH, CDK5, NF2, FASN, EWSR1 and MAP3K11) that result classified in the same functional cluster. These genes are also part of two gene networks, whose genes share the 'stress', 'cell death', 'inflammation' and 'immune response' GO terms. Combining CNV detection/association analysis based on two different algorithms helps towards a more complete identification of genes linked to phenotypic variation of the somatic cell count.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leche / Variaciones en el Número de Copia de ADN / Mastitis Bovina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Anim Breed Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2017 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leche / Variaciones en el Número de Copia de ADN / Mastitis Bovina Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: J Anim Breed Genet Asunto de la revista: GENETICA / MEDICINA VETERINARIA Año: 2017 Tipo del documento: Article Pais de publicación: Alemania