[Heparin-induced thrombocytopenia. New therapeutical options]. / Trombocitopenia inducida por heparina. Nuevas opciones terapéuticas.
Medicina (B Aires)
; 76(4): 230-4, 2016.
Article
en Es
| MEDLINE
| ID: mdl-27576282
Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse reaction due to antibodies to a multimolecular complex of heparin and platelet factor 4 (PF4) characterized by moderate thrombocytopenia and paradoxical arterial or venous thrombosis. It is a relatively infrequent complication related to the administration of any type of heparin. In patients undergoing percutaneous coronary revascularization or coronary artery by-pass graft the prevalence of HIT is higher than in other clinical settings. Recognizing clinical and laboratory features of HIT allow immediate discontinuation of heparin and the use of alternative anticoagulants to avoid serious thrombotic complications. In this review, we summarize different therapeutic options for the treatment of HIT with special emphasis on direct oral anticoagulants (DOACS) such as dabigatran, rivaroxaban and apixaban. DOACS might represent a therapeutic alternative for HIT treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trombocitopenia
/
Trombosis
/
Heparina
/
Antitrombinas
/
Anticoagulantes
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
Es
Revista:
Medicina (B Aires)
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Argentina