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Effect of Internal Jugular Vein Compression on Intracranial Hemorrhage in a Porcine Controlled Cortical Impact Model.
Sindelar, Brian; Bailes, Julian; Sherman, Sydney; Finan, John; Stone, James; Lee, John; Ahmadian, Saman; Zhou, Ying; Patel, Vimal; Smith, David.
Afiliación
  • Sindelar B; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
  • Bailes J; 2 Department of Neurosurgery, University of Florida , Gainesville, Florida.
  • Sherman S; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
  • Finan J; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
  • Stone J; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
  • Lee J; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
  • Ahmadian S; 3 Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem , Evanston, Illinois.
  • Zhou Y; 3 Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem , Evanston, Illinois.
  • Patel V; 4 Department of Research Institute, NorthShore University HealthSystem , Evanston, Illinois.
  • Smith D; 1 Department of Neurosurgery, NorthShore University HealthSystem , Evanston, Illinois.
J Neurotrauma ; 34(8): 1703-1709, 2017 04 15.
Article en En | MEDLINE | ID: mdl-27573472
Internal jugular vein (IJV) compression has been shown to reduce axonal injury in pre-clinical traumatic brain injury (TBI) models and clinical concussion studies. However, this novel approach to prophylactically mitigating TBI through venous congestion raises concerns of increasing the propensity for hemorrhage and hemorrhagic propagation. This study aims to test the safety of IJV compression in a large animal controlled cortical impact (CCI) injury model and the resultant effects on hemorrhage. Twelve swine were randomized to placement of a bilateral IJV compression collar (CCI+collar) or control/no collar (CCI) prior to CCI injury. A histological grading of the extent of hemorrhage, both subarachnoid (SAH) and intraparenchymal (IPH), was conducted in a blinded manner by two neuropathologists. Other various measures of TBI histology were also analyzed including: ß-amyloid precursor protein (ß-APP) expression, presence of degenerating neurons, extent of cerebral edema, and inflammatory infiltrates. Euthanized 5 h after injury, the CCI+collar animals exhibited a significant reduction in total SAH (p = 0.024-0.026) and IPH scores (p = 0.03-0.05) compared with the CCI animals. There was no statistically significant difference in scoring for the other markers of TBI (ß-APP, neuronal degeneration, cerebral edema, or inflammatory infiltration). In conclusion, IJV compression was shown to reduce hemorrhage (SAH and IPH) in the porcine CCI model when applied prior to injury. These results suggest the role of IJV compression for mitigation of not only axonal, but also hemorrhagic injury following TBI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral Traumática / Hemorragia Subaracnoidea Traumática / Lesiones Traumáticas del Encéfalo / Venas Yugulares Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemorragia Cerebral Traumática / Hemorragia Subaracnoidea Traumática / Lesiones Traumáticas del Encéfalo / Venas Yugulares Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: J Neurotrauma Asunto de la revista: NEUROLOGIA / TRAUMATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos