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Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain.
Kim, Yu Shin; Anderson, Michael; Park, Kyoungsook; Zheng, Qin; Agarwal, Amit; Gong, Catherine; Young, LeAnne; He, Shaoqiu; LaVinka, Pamela Colleen; Zhou, Fengquan; Bergles, Dwight; Hanani, Menachem; Guan, Yun; Spray, David C; Dong, Xinzhong.
Afiliación
  • Kim YS; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Neuroscience & Cell Biology, the University of Texas Medical Branch School of Medicine, 301 Univers
  • Anderson M; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Park K; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Zheng Q; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Agarwal A; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Gong C; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Saijilafu; Department of Orthopaedic Surgery, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Department of Orthopaedics, the First Affiliated Hospital, Orthopaedic Institute, Soochow University, People's Republic of China.
  • Young L; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • He S; Department of Anesthesiology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • LaVinka PC; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Zhou F; Department of Orthopaedic Surgery, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Bergles D; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Hanani M; Hadassah-Hebrew University Medical Center, Mt. Scopus, Jerusalem 91240, Israel.
  • Guan Y; Department of Anesthesiology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
  • Spray DC; The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  • Dong X; Departments of Neuroscience, Neurosurgery, and Dermatology, Center of Sensory Biology, the Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electroni
Neuron ; 91(5): 1085-1096, 2016 Sep 07.
Article en En | MEDLINE | ID: mdl-27568517
Primary sensory neurons in the DRG play an essential role in initiating pain by detecting painful stimuli in the periphery. Tissue injury can sensitize DRG neurons, causing heightened pain sensitivity, often leading to chronic pain. Despite the functional importance, how DRG neurons function at a population level is unclear due to the lack of suitable tools. Here we developed an imaging technique that allowed us to simultaneously monitor the activities of >1,600 neurons/DRG in live mice and discovered a striking neuronal coupling phenomenon that adjacent neurons tend to activate together following tissue injury. This coupled activation occurs among various neurons and is mediated by an injury-induced upregulation of gap junctions in glial cells surrounding DRG neurons. Blocking gap junctions attenuated neuronal coupling and mechanical hyperalgesia. Therefore, neuronal coupling represents a new form of neuronal plasticity in the DRG and contributes to pain hypersensitivity by "hijacking" neighboring neurons through gap junctions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Receptoras Sensoriales / Dolor Crónico / Ganglios Espinales / Hiperalgesia / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Receptoras Sensoriales / Dolor Crónico / Ganglios Espinales / Hiperalgesia / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos