A journey beyond apoptosis: new enigma of controlling metastasis by pro-apoptotic Par-4.

Rasool, Reyaz Ur; Nayak, Debasis; Chakraborty, Souneek; Katoch, Archana; Faheem, Mir Mohd; Amin, Hina; Goswami, Anindya

Rasool, Reyaz Ur; Nayak, Debasis; Chakraborty, Souneek; Katoch, Archana; Faheem, Mir Mohd; Amin, Hina; Goswami, Anindya.

Afiliación

Rasool RU; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
Nayak D; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Chakraborty S; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
Katoch A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Faheem MM; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.
Amin H; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.
Goswami A; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.

Clin Exp Metastasis ; 33(8): 757-764, 2016 12.

Article en En | MEDLINE | ID: mdl-27568374

RESUMEN

Prostate apoptotic response 4 (Par-4) is coined as a therapeutic protein since owing to its diverse physiologically relevant properties, especially in the cancer perspective. Albeit, Par-4 expression is not restricted to any specific tissue/organ, apart from cell death promotion (due to challenging threats), the other biological role of Par-4 is convincingly emerging. In the recent years, several laboratories have intended to dissect the signaling or mechanisms involved in Par-4 activation to augment apoptosis cascades but new developments in Par-4 research have widened its therapeutic potential. One of these important avenues is the prevention of metastasis by pro-apoptotic Par-4. In this review, we will focus on the therapeutic perspective of Par-4 with a special reference to its (Par-4) virgin prospect of devastating metastasis control.

Asunto(s)

Proteínas Reguladoras de la Apoptosis/genética; Apoptosis/genética; Metástasis de la Neoplasia/genética; Proteínas Reguladoras de la Apoptosis/biosíntesis; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Transducción de Señal

Palabras clave

AKT; E-cadherin; EMT; MMP-2; Metastasis; Par-4

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas Reguladoras de la Apoptosis / Metástasis de la Neoplasia Límite: Humans Idioma: En Revista: Clin Exp Metastasis Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos

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