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Hyperthermic intraperitoneal chemotherapy with paclitaxel or cisplatin in patients with stage III-C/IV ovarian cancer. Is there any difference?
Cascales-Campos, P; López-López, V; Gil, J; Arévalo-Pérez, J; Nieto, A; Barceló, F; Gil, E; Parrilla, P.
Afiliación
  • Cascales-Campos P; Unidad De Cirugía De La Carcinomatosis Peritoneal, Departamento De Cirugía General, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain. Electronic address: cascalescirugia@gmail.com.
  • López-López V; Unidad De Cirugía De La Carcinomatosis Peritoneal, Departamento De Cirugía General, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Gil J; Unidad De Cirugía De La Carcinomatosis Peritoneal, Departamento De Cirugía General, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Arévalo-Pérez J; Radiology Department, Memorial Sloan-Kettering Cancer Center, USA; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Nieto A; Unidad De Ginecología Oncológica, Servicio De Ginecología y Obstetricia, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Barceló F; Unidad De Ginecología Oncológica, Servicio De Ginecología y Obstetricia, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Gil E; Unidad De Cirugía De La Carcinomatosis Peritoneal, Departamento De Cirugía General, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
  • Parrilla P; Unidad De Cirugía De La Carcinomatosis Peritoneal, Departamento De Cirugía General, Spain; Peritoneal Carcinomatosis Unit, Department of Surgery, Virgen de la Arrixaca University Hospital, Murcia, Spain.
Surg Oncol ; 25(3): 164-70, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27566018
OBJETIVE: To compare the results of the administration of HIPEC with Paclitaxel or Cisplatin after cytoreduction in patients with stage IIIC-IV ovarian cancer, especially focused on disease-free survival. PATIENTS: We retrospectively analyzed a consecutive series of patients operated after being diagnosed with stage III-C/IV serous epithelial ovarian carcinoma. Patients included in the study were treated between January 2008 and March 2015. After cytoreduction, Paclitaxel (doses of 60 mg/m(2)O or Cisplatin (doses of 75 mg/m(2)) were used. RESULTS: A total of 111 patients were included. Median age was 61 years. In 60 of them (54%) Paclitaxel was used during HIPEC treatment and 51 patients (46%) were treated with Cisplatin. PCI was similar between groups (PCI = 11 in both cases). Median follow up was 34 months (12-96 months). The median disease free survival in Paclitaxel Group was 27 months and 33 months in Cisplatin Group (p = 0.551). In patients treated with Paclitaxel disease free survival rates at 1, 2, and 3 years were 79%, 60% and 46%. In patients treated with Cisplatin disease free survival at 1, 2, and 3 years were 64%, 50% and 40% respectively. After a multivariate analysis, incomplete cytoreduction (HR: 6.54, 95% CI 2.98-10.17, p < 0.01) and PCI >11 (HR: 2.15, 95% CI 1.42-6.68, p < 0.05) were identified as independent factors associated with a reduced disease-free survival. Cystotatic used was not relevant regarding disease free survival analysis. CONCLUSION: HIPEC with paclitaxel or cisplatin after cytoreduction in patients with ovarian cancer IIIC-IV has not shown different results in disease-free survival outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Glandulares y Epiteliales / Hipertermia Inducida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / Neoplasias Peritoneales / Protocolos de Quimioterapia Combinada Antineoplásica / Neoplasias Glandulares y Epiteliales / Hipertermia Inducida Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos