Your browser doesn't support javascript.
loading
Neutralizing Antibody Responses to Antigenically Drifted Influenza A(H3N2) Viruses among Children and Adolescents following 2014-2015 Inactivated and Live Attenuated Influenza Vaccination.
Levine, Min Z; Martin, Judith M; Gross, F Liaini; Jefferson, Stacie; Cole, Kelly Stefano; Archibald, Crystal Ann; Nowalk, Mary Patricia; Susick, Michael; Moehling, Krissy; Spencer, Sarah; Chung, Jessie R; Flannery, Brendan; Zimmerman, Richard K.
Afiliación
  • Levine MZ; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA mwl2@cdc.gov.
  • Martin JM; Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Gross FL; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Battelle, Atlanta, Georgia, USA.
  • Jefferson S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Cole KS; Department of Immunology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Archibald CA; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Nowalk MP; Department of Family Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Susick M; Department of Family Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Moehling K; Department of Family Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Spencer S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Atlanta, Georgia, USA.
  • Chung JR; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Atlanta Research and Education Foundation, Atlanta, Georgia, USA.
  • Flannery B; Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Zimmerman RK; Center for Vaccine Research, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA Department of Family Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, US
Clin Vaccine Immunol ; 23(10): 831-839, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27558294
Human influenza A(H3N2) viruses that predominated during the moderately severe 2014-2015 influenza season differed antigenically from the vaccine component, resulting in reduced vaccine effectiveness (VE). To examine antibody responses to 2014-2015 inactivated influenza vaccine (IIV) and live-attenuated influenza vaccine (LAIV) among children and adolescents, we collected sera before and after vaccination from 150 children aged 3 to 17 years enrolled at health care facilities. Hemagglutination inhibition (HI) assays were used to assess the antibody responses to vaccine strains. We evaluated cross-reactive antibody responses against two representative A(H3N2) viruses that had antigenically drifted from the A(H3N2) vaccine component using microneutralization (MN) assays. Postvaccination antibody titers to drifted A(H3N2) viruses were higher following receipt of IIV (MN geometric mean titers [GMTs], 63 to 68; 38 to 45% achieved seroconversion) versus LAIV (MN GMT, 22; only 3 to 5% achieved seroconversion). In 9- to 17-year-olds, the highest MN titers were observed among IIV-vaccinated individuals who had received LAIV in the previous season. Among all IIV recipients aged 3 to 17 years, the strongest predictor of antibody responses to the drifted viruses was the prevaccination titers to the vaccine strain. The results of our study suggest that in an antigenically drifted influenza season, vaccination still induced cross-reactive antibody responses to drifted circulating A(H3N2) viruses, although higher antibody titers may be required for protection. Antibody responses to drifted A(H3N2) viruses following vaccination were influenced by multiple factors, including vaccine type and preexisting immunity from prior exposure.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana / Subtipo H3N2 del Virus de la Influenza A / Anticuerpos Neutralizantes / Anticuerpos Antivirales / Antígenos Virales Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Vaccine Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Gripe Humana / Subtipo H3N2 del Virus de la Influenza A / Anticuerpos Neutralizantes / Anticuerpos Antivirales / Antígenos Virales Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Clin Vaccine Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos