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Hunger neurons drive feeding through a sustained, positive reinforcement signal.
Chen, Yiming; Lin, Yen-Chu; Zimmerman, Christopher A; Essner, Rachel A; Knight, Zachary A.
Afiliación
  • Chen Y; Department of Physiology, University of California, San Francisco, San Francisco, United States.
  • Lin YC; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
  • Zimmerman CA; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, United states.
  • Essner RA; Department of Physiology, University of California, San Francisco, San Francisco, United States.
  • Knight ZA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Elife ; 52016 08 24.
Article en En | MEDLINE | ID: mdl-27554486
The neural mechanisms underlying hunger are poorly understood. AgRP neurons are activated by energy deficit and promote voracious food consumption, suggesting these cells may supply the fundamental hunger drive that motivates feeding. However recent in vivo recording experiments revealed that AgRP neurons are inhibited within seconds by the sensory detection of food, raising the question of how these cells can promote feeding at all. Here we resolve this paradox by showing that brief optogenetic stimulation of AgRP neurons before food availability promotes intense appetitive and consummatory behaviors that persist for tens of minutes in the absence of continued AgRP neuron activation. We show that these sustained behavioral responses are mediated by a long-lasting potentiation of the rewarding properties of food and that AgRP neuron activity is positively reinforcing. These findings reveal that hunger neurons drive feeding by transmitting a positive valence signal that triggers a stable transition between behavioral states.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hambre / Conducta Alimentaria / Neuronas Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Elife Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hambre / Conducta Alimentaria / Neuronas Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Animals Idioma: En Revista: Elife Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido