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Histological changes in endocrine and exocrine pancreatic tissue from patients exposed to incretin-based therapies.
Ueberberg, Sandra; Jütte, Hendrik; Uhl, Waldemar; Schmidt, Wolfgang; Nauck, Michael; Montanya, Eduard; Tannapfel, Andrea; Meier, Juris.
Afiliación
  • Ueberberg S; Diabetes Division, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
  • Jütte H; Department of Pathology, Ruhr-University Bochum, Bochum, Germany.
  • Uhl W; Department of Surgery, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
  • Schmidt W; Diabetes Division, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
  • Nauck M; Diabetes Division, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
  • Montanya E; Bellvitge Hospital, Department of Endocrinology, Feixa Llarga s/n, Hospitalet de Llobregat, 08907, Barcelona, Spain.
  • Tannapfel A; Department of Pathology, Ruhr-University Bochum, Bochum, Germany.
  • Meier J; Diabetes Division, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
Diabetes Obes Metab ; 18(12): 1253-1262, 2016 12.
Article en En | MEDLINE | ID: mdl-27545110
AIMS: Incretin-based therapies have been associated with an increased risk of pancreatitis. Recently, various histological abnormalities have been reported in human pancreatic tissue from brain-dead organ donors who had been exposed to incretin-based drugs. In the present study we examined pancreatic tissue collected at surgery. METHODS: Human pancreatic tissue from 7 type 2-diabetic patients treated with incretin-based drugs (type 2-I), 6 diabetic patients without incretin treatment (type 2-NI), 11 patients without diabetes (no diabetes group) and 9 brain-dead organ donors (BDOD group) was examined. RESULTS: Fractional beta-cell area was reduced in the type 2-NI group compared to the group without diabetes (P < .05), but there was no difference compared to the type 2-I patients. Alpha-cell area (P = .30), beta-cell replication (P = .17) and alpha-cell replication (P = .91) were not different. There were also no differences in acinar cell (P = .13) and duct cell replication (P = .099). Insulin-positive duct cells were more frequent in the type 2-I and the BDOD groups (P = .034). No co-expression of insulin and glucagon was detected. Pancreatic intraepithelial neoplasia (PanIN) lesions were very rare, all low-grade (PanIN 1a and 1b) and tended to occur more frequently in the type 2-I group (P = .084). CONCLUSIONS: The present results did not reveal marked histological abnormalities in the pancreas of incretin-treated patients with type 2 diabetes. Low numbers of specimens available and a large inter-individual variability of the findings warrant caution regarding the interpretation of histological data concerning drug effects on the human pancreas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Neoplasias Pancreáticas / Carcinoma in Situ / Islotes Pancreáticos / Páncreas Exocrino / Diabetes Mellitus Tipo 2 / Incretinas / Células Acinares Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Diabetes Obes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Páncreas / Neoplasias Pancreáticas / Carcinoma in Situ / Islotes Pancreáticos / Páncreas Exocrino / Diabetes Mellitus Tipo 2 / Incretinas / Células Acinares Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Diabetes Obes Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido