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Balance in children with acute lymphoblastic leukemia.
Varedi, Mitra; McKenna, Raymond; Lamberg, Eric M.
Afiliación
  • Varedi M; Rehabilitation Research and Movement Performance Laboratory, Stony Brook University, New York, USA.
  • McKenna R; Rehabilitation Research and Movement Performance Laboratory, Stony Brook University, New York, USA.
  • Lamberg EM; Department of Physical Therapy, School of Health Technology and Management, Stony Brook University, New York, USA.
Pediatr Int ; 59(3): 293-302, 2017 Mar.
Article en En | MEDLINE | ID: mdl-27543960
BACKGROUND: Treatment for acute lymphoblastic leukemia (ALL) can affect balance via different mechanisms, including sensory and motor peripheral neuropathy, cognitive impairment, and reduced muscle strength and flexibility. To provide an overview of what is currently known about the effects of cancer treatment on balance in pediatric ALL patients and survivors, and of the predictors of poor balance, a review of the literature was conducted. METHODS: Five databases were searched for English-language original research articles on balance during or after treatment for pediatric ALL. RESULTS: From a total of nine studies, six identified significant balance problems in children with ALL during or after treatment. The percentage of patients or survivors with impaired balance varied between 27% and 69% during treatment, 7% and 65% a few years after completion of treatment, and 14% and 17% many years after the completion of treatment. Factors associated with impaired balance were higher body mass index; higher intrathecal methotrexate dose; cranial radiation; knee extensor weakness; and impaired cognition. CONCLUSION: Although heterogeneity between the studies regarding patient age; age at diagnosis; time since completion of treatment; and methods of quantifying balance make it difficult to reach a single conclusion, the evidence suggests that survivors may experience short- and/or long-term balance difficulties. While there is a need for additional studies to better understand the effects of impaired balance in survivors, clinicians treating both child and adult survivors of ALL need to be aware of these potential risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Equilibrio Postural / Leucemia-Linfoma Linfoblástico de Células Precursoras / Antineoplásicos Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Pediatr Int Asunto de la revista: PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Australia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Equilibrio Postural / Leucemia-Linfoma Linfoblástico de Células Precursoras / Antineoplásicos Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Pediatr Int Asunto de la revista: PEDIATRIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Australia