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Imaging nuclear, endoplasmic reticulum and plasma membrane events in real time.
Bader, Christie A; Sorvina, Alexandra; Simpson, Peter V; Wright, Phillip J; Stagni, Stefano; Plush, Sally E; Massi, Massimiliano; Brooks, Douglas A.
Afiliación
  • Bader CA; Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
  • Sorvina A; Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
  • Simpson PV; Department of Chemistry and Nanochemistry Research Institute, Curtin University, Bently, Australia.
  • Wright PJ; Department of Chemistry and Nanochemistry Research Institute, Curtin University, Bently, Australia.
  • Stagni S; Department of Industrial Chemistry 'Toso Montanari', University of Bologna, Italy.
  • Plush SE; Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
  • Massi M; Department of Chemistry and Nanochemistry Research Institute, Curtin University, Bently, Australia.
  • Brooks DA; Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia. doug.brooks@unisa.edu.au.
FEBS Lett ; 590(18): 3051-60, 2016 09.
Article en En | MEDLINE | ID: mdl-27543777
Live cell imaging can provide important information on cellular dynamics; however, the full utilisation of this technology has been hampered by the limitations of imaging reagents. Metal-based complexes have the potential to overcome many of the issues common to many current imaging agents. The rhenium (I)-based complex fac-[Re(CO)3 (1,10-phenanthroline)(4-pyridyltetrazolate)], herein referred to as ReZolve-ER(™) , shows promise as a live cell imaging agent with rapid cell uptake, low cytotoxicity, resistance to photobleaching and compatibility with multicolour imaging. ReZolve-ER(™) localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short- or long-time courses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Membrana Celular / Núcleo Celular / Retículo Endoplásmico / Imagen Molecular Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Membrana Celular / Núcleo Celular / Retículo Endoplásmico / Imagen Molecular Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido