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Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model.
Kurt, Atilla; Karanlik, Hasan; Soylu, Sinan; Özgür, Ilker; Soydinç, Hilal Oguz; Duranyildiz, Derya; Olgaç, Vakur; Sen, Fatma; Asoglu, Oktar.
Afiliación
  • Kurt A; Department of General Surgery, Cumhuriyet University School of Medicine, Sivas, Turkey.
  • Karanlik H; Institude of Oncology, Surgical Oncology Unit, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
  • Soylu S; Department of General Surgery, Cumhuriyet University School of Medicine, Sivas, Turkey.
  • Özgür I; Institude of Oncology, Surgical Oncology Unit, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
  • Soydinç HO; Department of Biochemistry, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
  • Duranyildiz D; Department of Biochemistry, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
  • Olgaç V; Department of Pathology, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey.
  • Sen F; Department of Medical Oncology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.
  • Asoglu O; Department of General Surgery, Istanbul Liv Hospital, Istanbul, Turkey.
Ulus Cerrahi Derg ; 32(3): 157-61, 2016.
Article en En | MEDLINE | ID: mdl-27528807
OBJECTIVE: We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model. MATERIALS AND METHODS: Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery. RESULTS: The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p<0.05). When all groups were compared, it was found that vascular endothelial growth factor levels decreased significantly only in the abdomen (p<0.05). Hydroxyproline levels and anastomosis bursting pressure were examined, and a statistical difference was found between groups (hydroxyproline p<0.05, bursting pressure p<0.05). However, when postoperative 1 day group was compared with the control group, it was found that there was no difference between groups according to these parameters (p>0.05), but when peroperative group was compared with the control group a significant decrease was observed in both parameters. Histopathological healing score was also evaluated. No statistical difference between groups was found. CONCLUSION: Twenty-four hours later from the operation, intraperitoneal cetuximab therapy may be a safe and feasible treatment for metastatic colorectal patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Ulus Cerrahi Derg Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies Idioma: En Revista: Ulus Cerrahi Derg Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía