FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.

Vidal-Martínez, Guadalupe; Vargas-Medrano, Javier; Gil-Tommee, Carolina; Medina, David; Garza, Nathan T; Yang, Barbara; Segura-Ulate, Ismael; Dominguez, Samantha J; Perez, Ruth G

Vidal-Martínez, Guadalupe; Vargas-Medrano, Javier; Gil-Tommee, Carolina; Medina, David; Garza, Nathan T; Yang, Barbara; Segura-Ulate, Ismael; Dominguez, Samantha J; Perez, Ruth G.

Afiliación

Vidal-Martínez G; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Vargas-Medrano J; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Gil-Tommee C; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Medina D; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Garza NT; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Yang B; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Segura-Ulate I; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Dominguez SJ; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905.
Perez RG; From the Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, Texas 79905 ruth.g.perez@ttuhsc.edu.

J Biol Chem ; 291(39): 20811-21, 2016 09 23.

Article en En | MEDLINE | ID: mdl-27528608

Asunto(s)

Envejecimiento/metabolismo; Factor Neurotrófico Derivado del Encéfalo/metabolismo; Clorhidrato de Fingolimod/farmacología; Motilidad Gastrointestinal/efectos de los fármacos; Enfermedad de Parkinson/tratamiento farmacológico; Precursores de Proteínas/metabolismo; alfa-Sinucleína/metabolismo; Envejecimiento/efectos de los fármacos; Envejecimiento/genética; Envejecimiento/patología; Animales; Factor Neurotrófico Derivado del Encéfalo/genética; Motilidad Gastrointestinal/genética; Humanos; Ratones; Ratones Transgénicos; Enfermedad de Parkinson/genética; Enfermedad de Parkinson/metabolismo; Enfermedad de Parkinson/patología; Precursores de Proteínas/genética; alfa-Sinucleína/genética

Palabras clave

Parkinson disease; alpha-synuclein (aSyn); gut; neurodegenerative disease; neuroprotection; pathology; preclinical assessment; synucleinopathy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Precursores de Proteínas / Envejecimiento / Factor Neurotrófico Derivado del Encéfalo / Alfa-Sinucleína / Clorhidrato de Fingolimod / Motilidad Gastrointestinal Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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