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The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability.
Ang, Richard; Abramowitz, Joel; Birnbaumer, Lutz; Gourine, Alexander V; Tinker, Andrew.
Afiliación
  • Ang R; William Harvey Heart Centre, Barts & The London School of Medicine and Dentistry, London, UK Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
  • Abramowitz J; Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
  • Birnbaumer L; Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.
  • Gourine AV; William Harvey Heart Centre, Barts & The London School of Medicine and Dentistry, London, UK.
  • Tinker A; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK a.tinker@qmul.ac.uk.
Physiol Rep ; 4(15)2016 08.
Article en En | MEDLINE | ID: mdl-27528004
The heart is controlled by the sympathetic and parasympathetic limbs of the autonomic nervous system with inhibitory signaling mechanisms recruited in both limbs. The aim of this study was to determine the role of inhibitory heterotrimeric G proteins in the central nervous mechanisms underlying autonomic control of the heart and its potential role in arrhythmogenesis. Mice with conditional deletion of the inhibitory heterotrimeric G protein GαO in the presympathetic area of the rostral ventral lateral medulla (RVLM) were generated to determine the role of GαO-mediated signalling in autonomic control and electrophysiological properties of the heart. GαO deletion within the RVLM was not associated with changes in heart rate (HR) or the arterial blood pressure at rest (home cage, normal behavior). However, exposure to stressful conditions (novel environment, hypoxia, or hypercapnia) in these mice was associated with abnormal HR responses and an increased baroreflex gain when assessed under urethane anesthesia. This was associated with shortening of the ventricular effective refractory period. This phenotype was reversed by systemic beta-adrenoceptor blockade, suggesting that GαO depletion in the RVLM increases central sympathetic drive. The data obtained support the hypothesis that GαO-mediated signaling within the presympathetic circuits of the RVLM contributes to the autonomic control of the heart. GαO deficiency in the RVLM has a significant impact on cardiovascular responses to stress, cardiovascular reflexes and electrical properties of the heart.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Autónomo / Bulbo Raquídeo / Subunidades alfa de la Proteína de Unión al GTP Gi-Go / Corazón Límite: Animals Idioma: En Revista: Physiol Rep Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Autónomo / Bulbo Raquídeo / Subunidades alfa de la Proteína de Unión al GTP Gi-Go / Corazón Límite: Animals Idioma: En Revista: Physiol Rep Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos