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Utilization of the Ability to Induce Activation of the Nuclear Factor (Erythroid-derived 2)-like Factor 2 (Nrf2) to Assess Potential Cancer Chemopreventive Activity of Liquorice Samples.
Basar, Norazah; Nahar, Lutfun; Oridupa, Olayinka Ayotunde; Ritchie, Kenneth J; Talukdar, Anupam D; Stafford, Angela; Kushiev, Habibjon; Kan, Asuman; Sarker, Satyajit D.
Afiliación
  • Basar N; Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310, Johor Bahru, Johor, Malaysia.
  • Nahar L; Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Oridupa OA; Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Ritchie KJ; Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Talukdar AD; Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
  • Stafford A; Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK.
  • Kushiev H; Department of Life Science and Bioinformatics, Assam University, Silchar, 788011, India.
  • Kan A; ADAS UK Ltd, Rosemaund, Preston Wynne, Hereford, HR1 3PG, UK.
  • Sarker SD; Gulistan State University, Gulistan, Uzbekistan.
Phytochem Anal ; 27(5): 233-8, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27527356
INTRODUCTION: Nuclear factor (erythroid-derived 2)-like factor 2 (Nrf2) is a transcription factor that regulates expression of many detoxification enzymes. Nrf2-antioxidant responsive element (Nrf2-ARE) signalling pathway can be a target for cancer chemoprevention. Glycyrrhiza glabra, common name, 'liquorice', is used as a sweetening and flavouring agent, and traditionally, to treat various ailments, and implicated to chemoprevention. However, its chemopreventive property has not yet been scientifically substantiated. OBJECTIVE: To assess the ability of liquorice root samples to induce Nrf2 activation correlating to their potential chemopreventive property. METHODS: The ability of nine methanolic extracts of liquorice root samples, collected from various geographical origins, to induce Nrf2 activation was determined by the luciferase reporter assay using the ARE-reporter cell line, AREc32. The antioxidant properties were determined by the 2,2-diphenyl-1-picryhydrazyl (DPPH) and the ferric-reducing antioxidant power (FRAP) assays. RESULTS: All extracts exhibited free-radical-scavenging property (RC50 = 136.39-635.66 µg/mL). The reducing capacity of ferrous ion was 214.46-465.59 µM Fe(II)/g. Nrf2 activation indicated that all extracts induced expression of ARE-driven luciferase activity with a maximum induction of 2.3 fold relative to control. These activities varied for samples from one geographical location to another. CONCLUSIONS: The present findings add to the existing knowledge of cancer chemoprevention by plant-derived extracts or purified phytochemicals, particularly the potential use of liquorice for this purpose. Copyright © 2016 John Wiley & Sons, Ltd.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimioprevención / Factor 2 Relacionado con NF-E2 / Glycyrrhiza Límite: Humans Idioma: En Revista: Phytochem Anal Asunto de la revista: BOTANICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimioprevención / Factor 2 Relacionado con NF-E2 / Glycyrrhiza Límite: Humans Idioma: En Revista: Phytochem Anal Asunto de la revista: BOTANICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido