Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation.

Peverelli, E; Giardino, E; Treppiedi, D; Locatelli, M; Vaira, V; Ferrero, S; Bosari, S; Lania, A G; Spada, A; Mantovani, G

Peverelli, E; Giardino, E; Treppiedi, D; Locatelli, M; Vaira, V; Ferrero, S; Bosari, S; Lania, A G; Spada, A; Mantovani, G.

Afiliación

Peverelli E; Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Electronic address: erika.peverelli@guest.unimi.it.
Giardino E; Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Treppiedi D; Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Locatelli M; Neurosurgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Vaira V; Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi" (INGM), Milan, Italy.
Ferrero S; Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan Medical School, Milan, Italy.
Bosari S; Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
Lania AG; Endocrine Unit, IRCCS Humanitas Clinical Institute, Rozzano, University of Milan, Milan, Italy.
Spada A; Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Mantovani G; Endocrine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Cancer Lett ; 381(2): 279-86, 2016 10 28.

Article en En | MEDLINE | ID: mdl-27519461

Asunto(s)

Factores Despolimerizantes de la Actina/metabolismo; Movimiento Celular; Neoplasias Hipofisarias/enzimología; Receptores de Dopamina D2/metabolismo; Quinasas Asociadas a rho/metabolismo; Factores Despolimerizantes de la Actina/genética; Adulto; Anciano; Antineoplásicos/farmacología; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Agonistas de Dopamina/farmacología; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Masculino; Persona de Mediana Edad; Invasividad Neoplásica; Fosforilación; Neoplasias Hipofisarias/tratamiento farmacológico; Neoplasias Hipofisarias/genética; Neoplasias Hipofisarias/patología; Mutación Puntual; Inhibidores de Proteínas Quinasas/farmacología; Receptores de Dopamina D2/agonistas; Transducción de Señal; Transfección; Células Tumorales Cultivadas; Quinasas Asociadas a rho/antagonistas & inhibidores

Palabras clave

Cofilin; Dopamine receptor type 2; Invasion; Migration; Pituitary tumor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Movimiento Celular / Receptores de Dopamina D2 / Factores Despolimerizantes de la Actina / Quinasas Asociadas a rho Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda

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