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Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study.
Albouy-Llaty, Marion; Limousi, Frédérike; Carles, Camille; Dupuis, Antoine; Rabouan, Sylvie; Migeot, Virginie.
Afiliación
  • Albouy-Llaty M; Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.
  • Limousi F; Health-Endocrine Disruptors-EXposome, Clinical Investigation Center, Inserm U1402, 86021 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.
  • Carles C; Teaching Hospital of Poitiers, Biology-Pharmacy-Public Health Pole, 2 rue de la Milétrie, BP577, 86021 Poitiers Cedex, France. marion.albouy-llaty@chu-poitiers.fr.
  • Dupuis A; Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. frederike.limousi@gmail.com.
  • Rabouan S; Epidemiology of Cancer and Environmental Exposures, Inserm U1219, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France. Camille.Carles@isped.u-bordeaux2.fr.
  • Migeot V; Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France. antoine.dupuis@univ-poitiers.fr.
Int J Environ Res Public Health ; 13(8)2016 08 09.
Article en En | MEDLINE | ID: mdl-27517943
BACKGROUND: The relationship between preterm birth (PTB) and endocrine disruptor exposure in drinking-water has only occasionally been studied. The objective of this work was to investigate the relation between exposure to atrazine metabolites, or atrazine/nitrate mixtures, in drinking-water during pregnancy and prevalence of PTB neonates, while taking neighborhood deprivation into account. METHOD: A historic cohort study in Deux-Sèvres, France, between 2005 and 2010 with a multiple imputation model for data of exposure to atrazine metabolites and a logistic regression were carried out. RESULTS: We included 13,654 mother/neonate pairs living in 279 different census districts. The prevalence of PTB was 4%. Average atrazine metabolite concentration was 0.019 ± 0.009 (0.014-0.080) µg/L and 39% of mothers lived in less deprived areas. The individual data were associated with risk of PTB. The risk of PTB when exposed to highest concentration of atrazine metabolite adjusted for confounders, was ORa 1.625 95% CI [0.975; 2.710]. Taking, or not, neighborhood deprivation into account did not change the result. Exposure to atrazine/nitrate mixtures remained non-significant. CONCLUSIONS: Even if we took neighborhood deprivation into account, we could not show a significant relationship between exposure to atrazine metabolites, or mixtures, in drinking-water during the second trimester of pregnancy and PTB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agua Potable / Áreas de Pobreza / Características de la Residencia / Nacimiento Prematuro / Disruptores Endocrinos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Int J Environ Res Public Health Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Agua Potable / Áreas de Pobreza / Características de la Residencia / Nacimiento Prematuro / Disruptores Endocrinos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Newborn / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Int J Environ Res Public Health Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza