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Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.
Ota, Yasushi; Ikemiyagi, Yoshihiro; Sato, Toshiya; Funakoshi, Tatsuo; Hiruta, Nobuyuki; Kitamura, Makoto; Bujo, Hideaki; Suzuki, Mitsuya.
Afiliación
  • Ota Y; Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan. Electronic address: yasushiota5610@yahoo.co.jp.
  • Ikemiyagi Y; Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan.
  • Sato T; Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, Japan.
  • Funakoshi T; CAI Business Unit, Siemens Healthcare Diagnostics K.K., Tokyo, Japan.
  • Hiruta N; Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
  • Kitamura M; Department of Pathology, Toho University Sakura Medical Center, Chiba, Japan.
  • Bujo H; Department of Clinical Laboratory, Toho University Sakura Medical Center, Chiba, Japan.
  • Suzuki M; Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan.
Allergol Int ; 65(4): 396-399, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27516133
BACKGROUND: Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany). METHODS: Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the inferior turbinate. RESULTS: The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the serum. CONCLUSIONS: Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cornetes Nasales / Inmunoglobulina E / Rinitis Alérgica / Mucosa Nasal Límite: Animals / Humans Idioma: En Revista: Allergol Int Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cornetes Nasales / Inmunoglobulina E / Rinitis Alérgica / Mucosa Nasal Límite: Animals / Humans Idioma: En Revista: Allergol Int Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido