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Antioxidative Theranostic Iron Oxide Nanoparticles toward Brain Tumors Imaging and ROS Production.
Richard, Sophie; Saric, Ana; Boucher, Marianne; Slomianny, Christian; Geffroy, Françoise; Mériaux, Sébastien; Lalatonne, Yoann; Petit, Patrice X; Motte, Laurence.
Afiliación
  • Richard S; Laboratoire CSPBAT, CNRS UMR 7244 UFR SMBH, Université Paris 13 Sorbonne Paris Cité, F-93017 Bobigny, France.
  • Saric A; Laboratoire de Toxicologie, Pharmacologie et Signalisation Cellulaire, INSERM U1124, Université Paris-Descartes, Centre Universitaire des Saints-Pères , F-75270 Paris Cedex 06, France.
  • Boucher M; Division of Molecular Medicine, Rudger Boskivic Institute , Zagreb, Croatia.
  • Slomianny C; Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
  • Geffroy F; Inserm, U100, Laboratoire de Physiologie Cellulaire, Université Lille 1 , F-59655 Villeneuve d'Ascq, France.
  • Mériaux S; Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
  • Lalatonne Y; Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191 Gif-sur-Yvette, France.
  • Petit PX; Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13 , Sorbonne Paris Cité, F-93017 Bobigny, France.
  • Motte L; Service de Médecine Nucléaire, Hôpital Avicenne Assistance Publique-Hôpitaux de Paris, F-93009 Bobigny, France.
ACS Chem Biol ; 11(10): 2812-2819, 2016 10 21.
Article en En | MEDLINE | ID: mdl-27513597
Gliomas are the most common primary brain tumor in humans. To date, the only treatment of care consists of surgical removal of the tumor bulk, irradiation, and chemotherapy, finally resulting in a very poor prognosis due to the lack of efficiency in diagnostics. In this context, nanomedicine combining both diagnostic and magnetic resonance imaging (MRI) and therapeutic applications is a relevant strategy referred to theranostic. Magnetic nanoparticles (NP) are excellent MRI contrast agents because of their large magnetic moment, which induces high transverse relaxivity (r2) characteristic and increased susceptibility effect (T2*). NP can be also used for drug delivery by coating their surface with therapeutic molecules. Preliminary in vitro studies show the high potential of caffeic acid (CA), a natural polyphenol, as a promising anticancer drug due to its antioxidant, anti-inflammatory, and antimetastatic properties. In this study, the antioxidative properties of iron oxide NP functionalized with caffeic acid (γFe2O3@CA NP) are investigated in vitro on U87-MG brain cancer cell lines. After intravenous injection of these NP in mice bearing a U87 glioblastoma, a negative contrast enhancement was specifically observed on 11.7 T MRI images in cancerous tissue, demonstrating a passive targeting of the tumor with these nanoplatforms.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Compuestos Férricos / Especies Reactivas de Oxígeno / Nanopartículas del Metal / Nanomedicina Teranóstica / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Chem Biol Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Compuestos Férricos / Especies Reactivas de Oxígeno / Nanopartículas del Metal / Nanomedicina Teranóstica / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: ACS Chem Biol Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos