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Growth differentiation factor 11 (GDF11) - a promising anti-ageing factor - is highly concentrated in platelets.
Bueno, J L; Ynigo, M; de Miguel, C; Gonzalo-Daganzo, R M; Richart, A; Vilches, C; Regidor, C; García-Marco, J A; Flores-Ballester, E; Cabrera, J R.
Afiliación
  • Bueno JL; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • Ynigo M; Immunology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • de Miguel C; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • Gonzalo-Daganzo RM; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • Richart A; Centro de Transfusión, Madrid, Spain.
  • Vilches C; Inmunogenetics & Histocompatibility, Instituto de Investigación Sanitaria Puerta de Hierro.
  • Regidor C; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • García-Marco JA; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
  • Flores-Ballester E; Centro de Transfusión, Madrid, Spain.
  • Cabrera JR; Haematology Department, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Spain.
Vox Sang ; 111(4): 434-436, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27509407
Recent research suggests that growth differentiation factor 11 (GDF11) could reverse age-related diseases and that its blood concentration decreases with age. This poses plasma from young donors as a therapeutic GDF11 source to treat age-related diseases. In addition, the tissue source of circulating GDF11 remains unknown. We analysed GDF11 levels in paired samples of serum, plasma and platelet lysate (PL) from 23 volunteers. Plasma and PL were collected by plateletpheresis. Here, we show that GDF11 is highly concentrated in platelets and that the circulating levels reported in previous studies could be biased as a result of serum sample manipulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Proteínas Morfogenéticas Óseas / Factores de Diferenciación de Crecimiento Límite: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Vox Sang Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Proteínas Morfogenéticas Óseas / Factores de Diferenciación de Crecimiento Límite: Adolescent / Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Vox Sang Año: 2016 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido