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How language flows when movements don't: An automated analysis of spontaneous discourse in Parkinson's disease.
García, Adolfo M; Carrillo, Facundo; Orozco-Arroyave, Juan Rafael; Trujillo, Natalia; Vargas Bonilla, Jesús F; Fittipaldi, Sol; Adolfi, Federico; Nöth, Elmar; Sigman, Mariano; Fernández Slezak, Diego; Ibáñez, Agustín; Cecchi, Guillermo A.
Afiliación
  • García AM; Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Av. Rivadavia 191
  • Carrillo F; National Scientific and Technical Research Council (CONICET), Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina; Department of Computer Science, School of Sciences, University of Buenos Aires, Pabellón I, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
  • Orozco-Arroyave JR; Faculty of Engineering, University of Antioquia, Calle 67 N° 53-108, C1226 Medellín, Colombia; Pattern Recognition Lab, Friedrich-Alexander-Universität, Martensstrasse 3, 91058 Erlangen-Nürnberg, Germany.
  • Trujillo N; Neuroscience Group, Faculty of Medicine, University of Antioquia, Calle 62 N° 52-59, C1226 Medellín, Colombia; School of Public Health, University of Antioquia, Calle 62 N° 52-59, C1226 Medellín, Colombia.
  • Vargas Bonilla JF; Faculty of Engineering, University of Antioquia, Calle 67 N° 53-108, C1226 Medellín, Colombia.
  • Fittipaldi S; Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina.
  • Adolfi F; Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina.
  • Nöth E; Pattern Recognition Lab, Friedrich-Alexander-Universität, Martensstrasse 3, 91058 Erlangen-Nürnberg, Germany.
  • Sigman M; Laboratory of Integrative Neuroscience, Torcuato Di Tella University, Av. Figueroa Alcorta 7350, C1428BCW Buenos Aires, Argentina.
  • Fernández Slezak D; National Scientific and Technical Research Council (CONICET), Av. Rivadavia 1917, C1033AAJ Buenos Aires, Argentina; Department of Computer Science, School of Sciences, University of Buenos Aires, Pabellón I, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
  • Ibáñez A; Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive and Translational Neuroscience (INCyT), INECO Foundation, Favaloro University, Pacheco de Melo 1860, C1126AAB Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Av. Rivadavia 191
  • Cecchi GA; Computational Biology Center, IBM, T.J. Watson Research Center, Yorktown Heights, 1101 Kitchawan Rd., Yorktwon Heights, New York, NY 10598, USA.
Brain Lang ; 162: 19-28, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27501386
To assess the impact of Parkinson's disease (PD) on spontaneous discourse, we conducted computerized analyses of brief monologues produced by 51 patients and 50 controls. We explored differences in semantic fields (via latent semantic analysis), grammatical choices (using part-of-speech tagging), and word-level repetitions (with graph embedding tools). Although overall output was quantitatively similar between groups, patients relied less heavily on action-related concepts and used more subordinate structures. Also, a classification tool operating on grammatical patterns identified monologues as pertaining to patients or controls with 75% accuracy. Finally, while the incidence of dysfluent word repetitions was similar between groups, it allowed inferring the patients' level of motor impairment with 77% accuracy. Our results highlight the relevance of studying naturalistic discourse features to tap the integrity of neural (and, particularly, motor) networks, beyond the possibilities of standard token-level instruments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Habla / Movimiento Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Brain Lang Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Habla / Movimiento Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Brain Lang Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos