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Antimicrobial and enhancement of the antibiotic activity by phenolic compounds: Gallic acid, caffeic acid and pyrogallol.
Lima, Valéria N; Oliveira-Tintino, Cícera D M; Santos, Enaide S; Morais, Luís P; Tintino, Saulo R; Freitas, Thiago S; Geraldo, Yuri S; Pereira, Raimundo L S; Cruz, Rafael P; Menezes, Irwin R A; Coutinho, Henrique D M.
Afiliación
  • Lima VN; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Oliveira-Tintino CD; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Santos ES; Laboratório de Farmacologia de Produtos Naturais, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Morais LP; Laboratório de Fisiofarmacologia de Células Excitáveis, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Tintino SR; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Freitas TS; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Geraldo YS; Faculdade Leão Sampaio, Juazeiro do Norte, CE, Brazil.
  • Pereira RL; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Cruz RP; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Menezes IR; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
  • Coutinho HD; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil. Electronic address: hdmcoutinho@gmail.com.
Microb Pathog ; 99: 56-61, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27497894
The indiscriminate use of antimicrobial drugs has increased the spectrum of exposure of these organisms. In our studies, these phenolic compounds were evaluated: gallic acid, caffeic acid and pyrogallol. The antibacterial, antifungal and modulatory of antibiotic activities of these compounds were assayed using microdilution method of Minimum Inhibitory Concentration (MIC) to bacteria and Minimum Fungicide Concentration (MFC) to fungi. The modulation was made by comparisons of the MIC and MFC of the compounds alone and combined with drugs against bacteria and fungi respectively, using a sub-inhibitory concentration of 128 µg/mL of substances (MIC/8). All substances not demonstrated clinically relevant antibacterial activity with a MIC above ≥1024 µg/mL. As a result, we observed that the caffeic acid presented a potentiating antibacterial effect over the 3 groups of bacteria studied. Pyrogallol showed a synergistic effect with two of the antibiotics tested, but only against Staphylococcus aureus. In general, caffeic acid was the substance that presented with the greatest number of antibiotics and with the greatest number of bacteria. In relation to the antifungal activity of all the compounds, the verified results were ≥1024 µg/mL, not demonstrating significant activity. Regarding potentiation of the effect of fluconazole, was observed synergistic effect only when assayed against Candida tropicalis, with all substances. Therefore, as can be seen, the compounds presented as substances that can be promising potentiating agents of antimicrobial drugs, even though they do not have direct antibacterial and antifungal action.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirogalol / Bacterias / Ácidos Cafeicos / Candida / Sinergismo Farmacológico / Ácido Gálico / Antiinfecciosos Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirogalol / Bacterias / Ácidos Cafeicos / Candida / Sinergismo Farmacológico / Ácido Gálico / Antiinfecciosos Idioma: En Revista: Microb Pathog Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido