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PAK4 Phosphorylates p53 at Serine 215 to Promote Liver Cancer Metastasis.
Xu, Hai-Tao; Lai, Wai-Lung; Liu, Heong-Fai; Wong, Leo Lap-Yan; Ng, Irene Oi-Lin; Ching, Yick Pang.
Afiliación
  • Xu HT; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
  • Lai WL; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
  • Liu HF; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
  • Wong LL; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China.
  • Ng IO; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China.
  • Ching YP; School of Biomedical Sciences, The University of Hong Kong, Hong Kong, China. State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong, China. Cancer Research Center, The University of Hong Kong, Hong Kong, China. ypching@hku.hk.
Cancer Res ; 76(19): 5732-5742, 2016 10 01.
Article en En | MEDLINE | ID: mdl-27496712
PAK4 kinase contributes to signaling pathways controlling cancer cell transformation, invasion, and survival, but its clinicopathological impact has begun to emerge only recently. Here we report that PAK4 overexpression in hepatocellular carcinoma (HCC) conveys aggressive metastatic properties. A novel nuclear splice isoform of PAK4 lacking exon 2 sequences was isolated as part of our studies. By stably overexpressing or silencing PAK4 in HCC cells, we showed that it was critical for their migration. Mechanistic investigations in this setting revealed that PAK4 directly phosphorylated p53 at S215, which not only attenuated transcriptional transactivation activity but also inhibited p53-mediated suppression of HCC cell invasion. Taken together, our results showed how PAK4 overexpression in HCC promotes metastatic invasion by regulating p53 phosphorylation. Cancer Res; 76(19); 5732-42. ©2016 AACR.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Quinasas p21 Activadas / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Quinasas p21 Activadas / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos