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Flow Cytometry in Detection of Fetal Red Blood Cells and Maternal F Cells to Identify Fetomaternal Hemorrhage.
Farias, Mariela Granero; Dal Bó, Suzane; Castro, Simone Martins de; da Silva, Aline Reis; Bonazzoni, Joyce; Scotti, Luciana; Costa, Sergio H Almeida Martins.
Afiliación
  • Farias MG; a Department of Clinical Pathology , Flow Cytometry, Hospital de Clínicas de Porto Alegre , Porto Alegre , Brazil.
  • Dal Bó S; b Department of Clinical Pathology , Hematology Unit, Hospital de Clínicas de Porto Alegre , Porto Alegre , Brazil.
  • Castro SM; c Universidade Federal do Rio Grande do Sul , School of Pharmacy , Porto Alegre , Brazil.
  • da Silva AR; d Hematology , Hospital de Clinicas de Porto Alegre , Porto Alegre , Brazil.
  • Bonazzoni J; c Universidade Federal do Rio Grande do Sul , School of Pharmacy , Porto Alegre , Brazil.
  • Scotti L; b Department of Clinical Pathology , Hematology Unit, Hospital de Clínicas de Porto Alegre , Porto Alegre , Brazil.
  • Costa SH; e Department of Obstetrics and Gynecology , Hospital de Clinicas de Porto Alegre , Porto Alegre , Brazil.
Fetal Pediatr Pathol ; 35(6): 385-391, 2016.
Article en En | MEDLINE | ID: mdl-27494244
Accurate detection and quantitation of fetomaternal hemorrhage (FMH) is critical to the obstetric management of rhesus D alloimmunization in Rh-negative pregnant women. The flow cytometry is based on the detection of fetal red blood cells using a monoclonal anti-HbF antibody, and is the method most indicated for this estimation. The objective of this study was to quantify fetal red blood cell levels of pregnant women using flow cytometry. We analyzed 101 peripheral blood samples from Rh-negative and Rh-positive women, whose mean age was 24 years (20-32 years), after vaginal delivery or cesarean section. Our study showed that 53% of pregnant women had fetal red blood cells levels <2.0 mL, 31% between 2.0-3.9 mL, 16% between 4.0-15.0 mL, and 1% >15.0 mL. Accurate quantitation of fetal red blood cells is necessary to determine the appropriate dose of anti-D (RHD) immunoglobulin to be administered to pregnant or postpartum women.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sangre Fetal / Transfusión Fetomaterna / Citometría de Flujo Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Fetal Pediatr Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sangre Fetal / Transfusión Fetomaterna / Citometría de Flujo Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Newborn / Pregnancy Idioma: En Revista: Fetal Pediatr Pathol Asunto de la revista: PATOLOGIA / PEDIATRIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido