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Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study.
Meyer Sauteur, Patrick M; Huizinga, Ruth; Tio-Gillen, Anne P; Roodbol, Joyce; Hoogenboezem, Theo; Jacobs, Enno; van Rijn, Monique; van der Eijk, Annemiek A; Vink, Cornelis; de Wit, Marie-Claire Y; van Rossum, Annemarie M C; Jacobs, Bart C.
Afiliación
  • Meyer Sauteur PM; Department of Pediatrics, Division of Pediatric Infectious Diseases and Immunology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
  • Huizinga R; Laboratory of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
  • Tio-Gillen AP; Division of Infectious Diseases and Hospital Epidemiology, and Children's Research Center (CRC), University Children's Hospital of Zurich, Zurich, Switzerland.
  • Roodbol J; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Hoogenboezem T; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • Jacobs E; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • van Rijn M; Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
  • van der Eijk AA; Department of Pediatrics, Division of Pediatric Neurology, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
  • Vink C; Laboratory of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, The Netherlands.
  • de Wit MC; TU Dresden, Medical Faculty Carl Gustav Carus, Institute of Medical Microbiology and Hygiene, Dresden, Germany.
  • van Rossum AM; Department of Neurology, Albert Schweitzer Hospital, Dordrecht, The Netherlands.
  • Jacobs BC; Department of Viroscience, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Ann Neurol ; 80(4): 566-80, 2016 10.
Article en En | MEDLINE | ID: mdl-27490360
OBJECTIVE: Guillain-Barré syndrome (GBS) is an acute postinfectious immune-mediated polyneuropathy. Although preceding respiratory tract infections with Mycoplasma pneumoniae have been reported in some cases, the role of M. pneumoniae in the pathogenesis of GBS remains unclear. We here cultured, for the first time, M. pneumoniae from a GBS patient with antibodies against galactocerebroside (GalC), which cross-reacted with the isolate. This case prompted us to unravel the role of M. pneumoniae in GBS in a case-control study. METHODS: We included 189 adults and 24 children with GBS and compared them to control cohorts for analysis of serum antibodies against M. pneumoniae (n = 479) and GalC (n = 198). RESULTS: Anti-M. pneumoniae immunoglobulin (Ig) M antibodies were detected in GBS patients and healthy controls in 3% and 0% of adults (p = 0.16) and 21% and 7% of children (p = 0.03), respectively. Anti-GalC antibodies (IgM and/or IgG) were found in 4% of adults and 25% of children with GBS (p = 0.001). Anti-GalC-positive patients showed more-frequent preceding respiratory symptoms, cranial nerve involvement, and a better outcome. Anti-GalC antibodies correlated with anti-M. pneumoniae antibodies (p < 0.001) and cross-reacted with different M. pneumoniae strains. Anti-GalC IgM antibodies were not only found in GBS patients with M. pneumoniae infection, but also in patients without neurological disease (8% vs 9%; p = 0.87), whereas anti-GalC IgG was exclusively found in patients with GBS (9% vs 0%; p = 0.006). INTERPRETATION: M. pneumoniae infection is associated with GBS, more frequently in children than adults, and elicits anti-GalC antibodies, of which specifically anti-GalC IgG may contribute to the pathogenesis of GBS. Ann Neurol 2016;80:566-580.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Síndrome de Guillain-Barré / Galactosilceramidas / Anticuerpos Antibacterianos / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Síndrome de Guillain-Barré / Galactosilceramidas / Anticuerpos Antibacterianos / Infecciones por Mycoplasma / Mycoplasma pneumoniae Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Neurol Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos