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CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles.
Leong, Yew Ann; Chen, Yaping; Ong, Hong Sheng; Wu, Di; Man, Kevin; Deleage, Claire; Minnich, Martina; Meckiff, Benjamin J; Wei, Yunbo; Hou, Zhaohua; Zotos, Dimitra; Fenix, Kevin A; Atnerkar, Anurag; Preston, Simon; Chipman, Jeffrey G; Beilman, Greg J; Allison, Cody C; Sun, Lei; Wang, Peng; Xu, Jiawei; Toe, Jesse G; Lu, Hao K; Tao, Yong; Palendira, Umaimainthan; Dent, Alexander L; Landay, Alan L; Pellegrini, Marc; Comerford, Iain; McColl, Shaun R; Schacker, Timothy W; Long, Heather M; Estes, Jacob D; Busslinger, Meinrad; Belz, Gabrielle T; Lewin, Sharon R; Kallies, Axel; Yu, Di.
Afiliación
  • Leong YA; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
  • Chen Y; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
  • Ong HS; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
  • Wu D; School of Dentistry, The University of North Carolina at Chapel Hill, North Carolina, USA.
  • Man K; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Deleage C; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Minnich M; AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Meckiff BJ; Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria.
  • Wei Y; Institute of Immunology and Immunotherapy, Centre for Human Virology and Cancer Immunology and Immunotherapy Centre, University of Birmingham, UK.
  • Hou Z; Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.
  • Zotos D; Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, China.
  • Fenix KA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Atnerkar A; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Preston S; Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
  • Chipman JG; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
  • Beilman GJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Allison CC; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Sun L; Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
  • Wang P; Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
  • Xu J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Toe JG; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Lu HK; Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Tao Y; Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  • Palendira U; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Dent AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Landay AL; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Pellegrini M; The Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.
  • Comerford I; Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
  • McColl SR; Centenary Institute, Newtown, Australia.
  • Schacker TW; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Long HM; Department of Immunology/Microbiology, Rush University Medical Center, Chicago, Illinois, USA.
  • Estes JD; The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
  • Busslinger M; The Department of Medical Biology, University of Melbourne, Parkville, Australia.
  • Belz GT; Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
  • Lewin SR; Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide, Adelaide, Australia.
  • Kallies A; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Yu D; Institute of Immunology and Immunotherapy, Centre for Human Virology and Cancer Immunology and Immunotherapy Centre, University of Birmingham, UK.
Nat Immunol ; 17(10): 1187-96, 2016 10.
Article en En | MEDLINE | ID: mdl-27487330
During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells' (TFC cells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3. Blimp1 and E2A directly regulated Cxcr5 expression and, together with Bcl6 and TCF-1, formed a transcriptional circuit that guided TFC cell development. The identification of TFC cells has far-reaching implications for the development of strategies to control infections that target B cells and TFH cells and to treat B cell-derived malignancies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T Citotóxicos / VIH / Infecciones por Arenaviridae / Infecciones por Virus de Epstein-Barr / Virus de la Coriomeningitis Linfocítica Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T Citotóxicos / VIH / Infecciones por Arenaviridae / Infecciones por Virus de Epstein-Barr / Virus de la Coriomeningitis Linfocítica Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos