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The host specificity of ape malaria parasites can be broken in confined environments.
Ngoubangoye, Barthélémy; Boundenga, Larson; Arnathau, Céline; Mombo, Illich Manfred; Durand, Patrick; Tsoumbou, Thierry-Audrey; Otoro, Bertony Vacky; Sana, Rick; Okouga, Alain-Prince; Moukodoum, Nancy; Willaume, Eric; Herbert, Anaïs; Fouchet, David; Rougeron, Virginie; Bâ, Cheikh Tidiane; Ollomo, Benjamin; Paupy, Christophe; Leroy, Eric M; Renaud, François; Pontier, Dominique; Prugnolle, Franck.
Afiliación
  • Ngoubangoye B; Centre de Primatologie, CIRMF, B.P. 769, Franceville, Gabon; Laboratoire de Biométrie et Biologie Evolutive, UMR5558, Université Lyon 1, France; LabEx ECOFECT, Eco-evolutionary Dynamics of Infectious Diseases, University of Lyon, France. Electronic address: genistha@hotmail.com.
  • Boundenga L; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon; Laboratoire d'Écologie et Biologie Evolutive, Département de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, BP5005, Senegal. Electronic address: larsonamedeo@
  • Arnathau C; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
  • Mombo IM; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France; Département de Zoonoses et maladies émergentes, CIRMF, B.P. 769, Franceville, Gabon.
  • Durand P; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
  • Tsoumbou TA; Centre de Primatologie, CIRMF, B.P. 769, Franceville, Gabon.
  • Otoro BV; Centre de Primatologie, CIRMF, B.P. 769, Franceville, Gabon.
  • Sana R; Centre de Primatologie, CIRMF, B.P. 769, Franceville, Gabon.
  • Okouga AP; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon.
  • Moukodoum N; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon.
  • Willaume E; Parc de La Lékédi, Société d'Exploitation du Parc de La Lékédi/Entreprise de Recherche et d'Activités Métallurgiques/Compagnie Minière de l'Ogooué, BP 52, Bakoumba, Gabon.
  • Herbert A; Centre de Primatologie, CIRMF, B.P. 769, Franceville, Gabon.
  • Fouchet D; Laboratoire de Biométrie et Biologie Evolutive, UMR5558, Université Lyon 1, France; LabEx ECOFECT, Eco-evolutionary Dynamics of Infectious Diseases, University of Lyon, France.
  • Rougeron V; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
  • Bâ CT; Laboratoire d'Écologie et Biologie Evolutive, Département de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta Diop de Dakar, BP5005, Senegal.
  • Ollomo B; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon.
  • Paupy C; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
  • Leroy EM; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
  • Renaud F; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon.
  • Pontier D; Laboratoire de Biométrie et Biologie Evolutive, UMR5558, Université Lyon 1, France; LabEx ECOFECT, Eco-evolutionary Dynamics of Infectious Diseases, University of Lyon, France.
  • Prugnolle F; Unité de Biodiversité, Ecologie et Evolution des Parasites, CIRMF, B.P. 769, Franceville, Gabon; Laboratoire MIVEGEC, UM-CNRS 5290-IRD 224, IRD Montpellier, France.
Int J Parasitol ; 46(11): 737-44, 2016 10.
Article en En | MEDLINE | ID: mdl-27486075
Recent studies have revealed a large diversity of Plasmodium spp. among African great apes. Some of these species are related to Plasmodium falciparum, the most virulent agent of human malaria (subgenus Laverania), and others to Plasmodium ovale, Plasmodium malariae and Plasmodium vivax (subgenus Plasmodium), three other human malaria agents. Laverania parasites exhibit strict host specificity in their natural environment. Plasmodium reichenowi, Plasmodium billcollinsi, Plasmodium billbrayi and Plasmodium gaboni infect only chimpanzees, while Plasmodium praefalciparum, Plasmodium blacklocki and Plasmodium adleri are restricted to gorillas and Plasmodium falciparum is pandemic in humans. This host specificity may be due to genetic and/or environmental factors. Infrastructures hosting captive primates, such as sanctuaries and health centres, usually concentrate different primate species, thus favouring pathogen exchanges. Using molecular tools, we analysed blood samples from captive non-human primates living in Gabon to evaluate the risk of Plasmodium spp. transfers between host species. We also included blood samples from workers taking care of primates to assess whether primate-human parasite transfers occurred. We detected four transfers of Plasmodium from gorillas towards chimpanzees, one from chimpanzees to gorillas, three from humans towards chimpanzees and one from humans to mandrills. No simian Plasmodium was found in the blood samples from humans working with primates. These findings demonstrate that the genetic barrier that determines the apparent host specificity of Laverania is not completely impermeable and that parasite exchanges between gorillas and chimpanzees are possible in confined environments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Enfermedades de los Primates / Especificidad del Huésped / Malaria Tipo de estudio: Etiology_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Int J Parasitol Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Enfermedades de los Primates / Especificidad del Huésped / Malaria Tipo de estudio: Etiology_studies Límite: Animals / Humans País/Región como asunto: Africa Idioma: En Revista: Int J Parasitol Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido