Regulation of B cell functions by Toll-like receptors and complement.

Kremlitzka, Mariann; Mácsik-Valent, Bernadett; Erdei, Anna

Kremlitzka, Mariann; Mácsik-Valent, Bernadett; Erdei, Anna.

Afiliación

Kremlitzka M; MTA-ELTE Immunology Research Group, Budapest, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary.
Mácsik-Valent B; Department of Immunology, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary.
Erdei A; MTA-ELTE Immunology Research Group, Budapest, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary; Department of Immunology, Eötvös Loránd University, Pázmány Péter s. 1/C, Budapest H-1117, Hungary. Electronic address: anna.erdei@freemail.hu.

Immunol Lett ; 178: 37-44, 2016 10.

Article en En | MEDLINE | ID: mdl-27485187

RESUMEN

B cell functions triggered by the clonally-rearranged antigen-specific B cell receptor (BCR) are regulated by several germ-line encoded receptors - including Toll-like receptors (TLRs) and complement receptors (CRs). Simultaneous or sequential engagement of these structures expressed either on the cell membrane or intracellularly, may fundamentally alter and fine tune activation, antibody and cytokine production of B cells. Here we review the expression and function of TLRs and various C3 fragment binding CRs on B cells, emphasizing their role in different human B cell subsets under physiological and pathological conditions. Studies underlining the importance of the crosstalk between TLRs and CRs in regulating B cell functions are also highlighted.

Asunto(s)

Linfocitos B/inmunología; Linfocitos B/metabolismo; Proteínas del Sistema Complemento/inmunología; Proteínas del Sistema Complemento/metabolismo; Inmunomodulación; Receptores Toll-Like/metabolismo; Animales; Autoinmunidad; Susceptibilidad a Enfermedades; Regulación de la Expresión Génica; Humanos; Inmunidad Innata; Unión Proteica; Receptores de Complemento/metabolismo; Transducción de Señal

Palabras clave

B cells; Complement system; Crosstalk; TLR

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas del Sistema Complemento / Linfocitos B / Receptores Toll-Like / Inmunomodulación Límite: Animals / Humans Idioma: En Revista: Immunol Lett Año: 2016 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos

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