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Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Bhide, Rajeev S; Neels, James; Qin, Lan-Ying; Ruan, Zheming; Stachura, Sylwia; Weigelt, Carolyn; Sack, John S; Stefanski, Kevin; Gu, Xiaomei; Xie, Jenny H; Goldstine, Christine B; Skala, Stacey; Pedicord, Donna L; Ruepp, Stefan; Dhar, T G Murali; Carter, Percy H; Salter-Cid, Luisa M; Poss, Michael A; Davies, Paul.
Afiliación
  • Bhide RS; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States. Electronic address: rajeev.bhide@bms.com.
  • Neels J; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Qin LY; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Ruan Z; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Stachura S; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Weigelt C; Molecular structure and design, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Sack JS; Molecular structure and design, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Stefanski K; PCO discovery, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Gu X; PCO discovery, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Xie JH; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Goldstine CB; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Skala S; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Pedicord DL; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Ruepp S; PCO discovery, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Dhar TG; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Carter PH; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Salter-Cid LM; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Poss MA; Discovery chemistry, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
  • Davies P; Immunoscience biology, Research & Development, Bristol-Myers Squibb Company, Route 206 & Province Line Road, Princeton, NJ 08534, United States.
Bioorg Med Chem Lett ; 26(17): 4256-60, 2016 09 01.
Article en En | MEDLINE | ID: mdl-27476421
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Inhibidores de Proteínas Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 / Aminas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazinas / Inhibidores de Proteínas Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 / Aminas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido