Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish.
Comp Biochem Physiol C Toxicol Pharmacol
; 189: 44-53, 2016 Nov.
Article
en En
| MEDLINE
| ID: mdl-27475025
The importance of histamine in the physiology of the testis in mammals and reptiles has been recently shown. Histamine receptors (Hrs) are well conserved in fish and are functional in several fish species. We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream. Moreover, cimetidine, which acts in vitro as an agonist of Hrh1 and Hrh2 on this species, was intraperitoneally injected in one and two years old gilthead seabream males. After three and five days of cimetidine injection, we found that this compound differently modified the gonadal hrs transcript levels and affects the testicular cell renewal and the gene expression of steroidogenesis-related molecules as well as the serum steroid levels. Our data point to cimetidine as a reproductive disruptor and elucidate a role for histamine in the gonad of this hermaphrodite fish species through Hr signalling.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Hormonas Esteroides Gonadales
/
Testículo
/
Cimetidina
/
Dorada
/
Disruptores Endocrinos
/
Organismos Hermafroditas
/
Antagonistas de los Receptores H2 de la Histamina
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Toxicol Pharmacol
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Estados Unidos