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Structural analysis and cytokine-induced activity of gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis.
Kravchenko, Anna O; Anastyuk, Stanislav D; Sokolova, Ekaterina V; Isakov, Vladimir V; Glazunov, Valery P; Helbert, William; Yermak, Irina M.
Afiliación
  • Kravchenko AO; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation. Electronic address: kravchenko_25.89@mail.ru.
  • Anastyuk SD; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation.
  • Sokolova EV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation.
  • Isakov VV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation.
  • Glazunov VP; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation.
  • Helbert W; CERMAV, CNRS and Grenoble Alpes Université, BP53, 38000 Grenoble Cedex 9, France.
  • Yermak IM; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 100 Let Vladivostoku Prosp., 159, 690022, Vladivostok, Russian Federation.
Carbohydr Polym ; 151: 523-534, 2016 Oct 20.
Article en En | MEDLINE | ID: mdl-27474596
Gelling sulfated polysaccharide from the cystocarpic plants of Ahnfeltiopsis flabelliformis was studied. According to FT-IR and NMR spectroscopy data, the polysaccharide was found to be iota/kappa-carrageenan with iota- and kappa-type units in a 2:1 ratio containing beta-carrageenan units and minor amounts of nu- and mu-carrageenans. The HPLC and ESI MS/MS data of enzymatic hydrolysis products revealed that the main components of the polymer chain are iota-carrabiose, iota-carratetraose and hybrid tetra- and hexasaccharides consisting of kappa- and iota-units. Xylose was a substituent of a hydroxyl group at C-6 of 1,3-linked ß-d-galactose in the total polysaccharides. It was shown that the ability of carrageenans to increase the synthesis of cytokines depended on their molecular weight. The polysaccharide induced the synthesis of the anti-inflammatory cytokine IL-10, whereas oligosaccharides increased the synthesis of both pro- and anti-inflammatory cytokines at high concentrations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Factor de Necrosis Tumoral alfa / Interleucina-10 / Rhodophyta Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Factor de Necrosis Tumoral alfa / Interleucina-10 / Rhodophyta Límite: Humans Idioma: En Revista: Carbohydr Polym Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido