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2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside.
Beutler, E; Piro, L D; Saven, A; Kay, A C; McMillan, R; Longmire, R; Carrera, C J; Morin, P; Carson, D A.
Afiliación
  • Beutler E; a Department of Molecular, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Piro LD; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Saven A; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Kay AC; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • McMillan R; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Longmire R; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Carrera CJ; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Morin P; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
  • Carson DA; b Experimental Medicine Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA.
Leuk Lymphoma ; 5(1): 1-8, 1991.
Article en En | MEDLINE | ID: mdl-27463204
Hereditary adenosine deaminase deficiency results in failure of the lymphocyte development. This occurs because of the accumulation of deoxyadenine nucleotides in cells with high deoxycytidine kinase and low 5'-nucleotidase activity. 2-Chlorodeoxyadenosine (2-CdA) resists the action of adenosine deaminase and accumulates in cells with high deoxycytidine kinase and low 5'-nucleotidase activity. It is equally toxic to dividing and nondividing cells and may act by preventing repair of DNA single-strand breaks. In doses of 0.1 mg/kg/day given for seven days 2-CdA manifests low toxicity. It has been found to be effective in the treatment of patients with lymphoid neoplasms, including advanced cutaneous T-cell lymphomas, chronic lymphocytic leukemia, non-Hodgkin lymphomas, and hairy cell leukemia. In the latter disorder it appears to be as or more effective than the tight-binding adenosine deaminase inhibitor, deoxycoformycin, and is probably less toxic. 2-CdA also appears to be effective in controlling autoimmune hemolytic anemia and shows promise in the treatment of other autoimmune diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 1991 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 1991 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos