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Cross-sectional retrospective study of muscle function in patients with glycogen storage disease type III.
Decostre, Valérie; Laforêt, Pascal; Nadaj-Pakleza, Aleksandra; De Antonio, Marie; Leveugle, Sylvain; Ollivier, Gwenn; Canal, Aurélie; Kachetel, Kahina; Petit, François; Eymard, Bruno; Behin, Anthony; Wahbi, Karim; Labrune, Philippe; Hogrel, Jean-Yves.
Afiliación
  • Decostre V; Institut de Myologie, APHP - GH Pitié-Salpêtrière, Bd de l'Hôpital, Paris 75651 Cedex 13, France. Electronic address: v.decostre@institut-myologie.org.
  • Laforêt P; Paris-Est Neuromuscular Center , APHP - GH Pitié-Salpêtrière, Paris, France; INSERM UMRS 974, Paris, France.
  • Nadaj-Pakleza A; Centre de référence des maladies neuromusculaires Nantes/Angers, Service de Neurologie, CHU Angers, Angers, France.
  • De Antonio M; INSERM U1138-team22, Centre de Recherche des Cordeliers, Paris Descartes and UPMC University, Paris, France.
  • Leveugle S; INSERM U1138-team22, Centre de Recherche des Cordeliers, Paris Descartes and UPMC University, Paris, France.
  • Ollivier G; Institut de Myologie, APHP - GH Pitié-Salpêtrière, Bd de l'Hôpital, Paris 75651 Cedex 13, France.
  • Canal A; Institut de Myologie, APHP - GH Pitié-Salpêtrière, Bd de l'Hôpital, Paris 75651 Cedex 13, France.
  • Kachetel K; Paris-Est Neuromuscular Center , APHP - GH Pitié-Salpêtrière, Paris, France.
  • Petit F; Laboratoire de Génétique moléculaire, APHP - GH Antoine Béclère, Clamart, France.
  • Eymard B; Paris-Est Neuromuscular Center , APHP - GH Pitié-Salpêtrière, Paris, France.
  • Behin A; Paris-Est Neuromuscular Center , APHP - GH Pitié-Salpêtrière, Paris, France.
  • Wahbi K; Institut de Myologie, APHP - GH Pitié-Salpêtrière, Bd de l'Hôpital, Paris 75651 Cedex 13, France; Département de Cardiologie, APHP, Hôpital Cochin, Paris, France.
  • Labrune P; APHP, Hôpital Antoine Béclère, Centre de Référence Maladies Héréditaires du Métabolisme Hépatique, Hôpitaux Universitaires Paris Sud, Clamart, France; Université Paris Sud, Orsay, France.
  • Hogrel JY; Institut de Myologie, APHP - GH Pitié-Salpêtrière, Bd de l'Hôpital, Paris 75651 Cedex 13, France.
Neuromuscul Disord ; 26(9): 584-92, 2016 09.
Article en En | MEDLINE | ID: mdl-27460348
Glycogen storage disease type III is an inherited metabolic disorder characterized by liver and muscle impairment. This study aimed to identify promising muscle function measures for future studies on natural disease progression and therapeutic trials. The age-effect on the manual muscle testing (MMT), the hand-held dynamometry (HHD), the motor function measure (MFM) and the Purdue pegboard test was evaluated by regression analysis in a cross-sectional retrospective single site study. In patients aged between 13 and 56 years old, the Purdue pegboard test and dynamometry of key pinch and knee extension strength were age-sensitive with annual losses of 1.49, 1.10 and 0.70% of the predicted values (%pred), respectively. The MFM score and handgrip strength were also age-sensitive but only in patients older than 29 and 37 years old with annual losses of 1.42 and 1.84%pred, respectively. Muscle strength assessed by MMT and elbow extension measured by HHD demonstrated an annual loss of less than 0.50%pred and are thus unlikely to be promising outcome measures for future clinical trials. In conclusion, our results identified age-sensitive outcomes from retrospective data and may serve for future longitudinal studies in which an estimation of the minimal number of subjects is provided.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Almacenamiento de Glucógeno Tipo III / Músculo Esquelético Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuromuscul Disord Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad del Almacenamiento de Glucógeno Tipo III / Músculo Esquelético Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuromuscul Disord Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido