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Systemic transcriptome analysis of hepatocellular carcinoma.
Yu, Cheng-Bo; Zhu, Li-Yao; Wang, Yu-Gang; Li, Fen; Zhang, Xiao-Yu; Dai, Wei-Jie.
Afiliación
  • Yu CB; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd., Hangzhou, 310003, China.
  • Zhu LY; Department of Hepatology, the Fourth People's Hospital of Huai'an, Huai'an, China.
  • Wang YG; Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Li F; Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430071, China.
  • Zhang XY; Division of Gastrointestinal Surgery, Department of General Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, China. yllzxy@163.com.
  • Dai WJ; Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China. daiweijie_yy@163.com.
Tumour Biol ; 37(10): 13323-13331, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27460080
Liver cancer is one of the most common malignant tumors, and most of which is hepatocellular carcinoma (HCC). We aim to study the characteristic changes of numerous genes and their roles in HCC through systematical analysis of the characteristics of expression spectrum of HCC. Firstly, we made systematic clustering of the HCC samples according to the RNAseq data from TCGA (The Cancer Genome Atlas) and newly classified HCC. Then the characteristic genes in different molecular subtypes were found out and further analyzed combing with methylation and SNP 6.0 chip. Finally, these genes were subjected to do functional annotation and abnormal signaling pathways of HCC in various molecular subtypes and were screened out. There were 3843 differential genes screened; among which, 689 genes were enriched into 13 KEGG-related pathways, and the expression of 27 and 924 genes showed positive and negative correlation to methylation level, respectively, while the expression of 43 genes showed positive correlation to variation level of copy number. The methylation degree of ZSCAN18 may be considered as a marker for prognosis evaluation, and ABHD6 could be a potential anti-oncogene.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Transcriptoma / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Transcriptoma / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos