Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE).

Karade, Hitendra N; Raviraju, G; Acharya, B N; Valiveti, Aditya Kapil; Bhalerao, Uma; Acharya, Jyotiranjan

Karade, Hitendra N; Raviraju, G; Acharya, B N; Valiveti, Aditya Kapil; Bhalerao, Uma; Acharya, Jyotiranjan.

Afiliación

Karade HN; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Raviraju G; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Acharya BN; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Valiveti AK; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Bhalerao U; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India.
Acharya J; Process Technology Development Division, Defence Research & Development Establishment, Jhansi Road, Gwalior 474002, India. Electronic address: jracharya01@gmail.com.

Bioorg Med Chem ; 24(18): 4171-4176, 2016 09 15.

Article en En | MEDLINE | ID: mdl-27450532

Asunto(s)

Acetamidas/química; Aminopiridinas/química; Reactivadores de la Colinesterasa/química; Niacinamida/análogos & derivados; Niacinamida/química; Oximas/química; Acetamidas/síntesis química; Aminopiridinas/síntesis química; Inhibidores de la Colinesterasa/química; Reactivadores de la Colinesterasa/síntesis química; Membrana Eritrocítica/enzimología; Humanos; Cinética; Niacinamida/síntesis química; Cloruro de Obidoxima/química; Compuestos Organotiofosforados/química; Oximas/síntesis química; Compuestos de Pralidoxima/química; Sarín/química

Palabras clave

2-(Hydroxyimino)-N-(pyridin-3-yl)acetamide; Acetylcholinesterase; Isonicotinamide; Nerve agents; Organophosphorus

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oximas / Reactivadores de la Colinesterasa / Niacinamida / Aminopiridinas / Acetamidas Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google