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Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.
Minu, Maninder; Singh, Deepti; Mahaddalkar, Tejashree; Lopus, Manu; Winter, Philip; Ayoub, Ahmed T; Missiaen, Kristal; Tilli, Tatiana Martins; Pasdar, Manijeh; Tuszynski, Jack.
Afiliación
  • Minu M; Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra 282110, India. Electronic address: minu.maninder@gmail.com.
  • Singh D; Department of Chemistry, Dayalbagh Educational Institute, Dayalbagh, Agra 282110, India.
  • Mahaddalkar T; Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Kalina, Mumbai 400098, India.
  • Lopus M; Experimental Cancer Therapeutics and Chemical Biology, UM-DAE Centre for Excellence in Basic Sciences, University of Mumbai, Kalina, Mumbai 400098, India.
  • Winter P; Division of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
  • Ayoub AT; Division of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
  • Missiaen K; Division of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
  • Tilli TM; Laboratório de Modelagem de Sistemas Biológicos, National Institute of Science and Technology for Innovation in Neglected Diseases (INCT/IDN, CNPq), Centro de Desenvolvimento Tecnológico em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Pasdar M; Division of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
  • Tuszynski J; Division of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada.
Bioorg Med Chem Lett ; 26(16): 3855-61, 2016 08 15.
Article en En | MEDLINE | ID: mdl-27449957
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Antineoplásicos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido