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Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.
Chang, S Y; Weber, E J; Ness, Kp Van; Eaton, D L; Kelly, E J.
Afiliación
  • Chang SY; Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, Washington, USA.
  • Weber EJ; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
  • Ness KV; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
  • Eaton DL; Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, Washington, USA.
  • Kelly EJ; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA. edkelly@uw.edu.
Clin Pharmacol Ther ; 100(5): 464-478, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27448090
Because of complex cellular microenvironments of both the liver and kidneys, accurate modeling of transport function has remained a challenge, leaving a dire need for models that can faithfully recapitulate both the architecture and cell-cell interactions observed in vivo. The study of hepatic and renal transport function is a fundamental component of understanding the metabolic fate of drugs and xenobiotics; however, there are few in vitro systems conducive for these types of studies. For both the hepatic and renal systems, we provide an overview of the location and function of the most significant phase I/II/III (transporter) of enzymes, and then review current in vitro systems for the suitability of a transporter function study and provide details on microphysiological systems that lead the field in these investigations. Microphysiological modeling of the liver and kidneys using "organ-on-a-chip" technologies is rapidly advancing in transport function assessment and has emerged as a promising method to evaluate drug and xenobiotic metabolism. Future directions for the field are also discussed along with technical challenges encountered in complex multiple-organs-on-chips development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Farmacocinética / Inactivación Metabólica / Procedimientos Analíticos en Microchip / Riñón / Hígado Límite: Animals / Humans Idioma: En Revista: Clin Pharmacol Ther Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas de Transporte de Membrana / Farmacocinética / Inactivación Metabólica / Procedimientos Analíticos en Microchip / Riñón / Hígado Límite: Animals / Humans Idioma: En Revista: Clin Pharmacol Ther Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos