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Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study.
Gerin, Mattia I; Fichtenholtz, Harlan; Roy, Alicia; Walsh, Christopher J; Krystal, John H; Southwick, Steven; Hampson, Michelle.
Afiliación
  • Gerin MI; Yale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Division of Psychology and Language Sciences, University College London (UCL), London, UK; Anna Freud Centre, London, UK; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
  • Fichtenholtz H; Department of Veteran Affairs, National Center for PTSD, West Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Bennington College, Bennington, VT, USA.
  • Roy A; Department of Veteran Affairs, National Center for PTSD, West Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Walsh CJ; Department of Radiology and Biomedical Imaging, Yale School of Medicine , New Haven, CT , USA.
  • Krystal JH; Department of Veteran Affairs, National Center for PTSD, West Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Southwick S; Department of Veteran Affairs, National Center for PTSD, West Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Hampson M; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Front Psychiatry ; 7: 111, 2016.
Article en En | MEDLINE | ID: mdl-27445868
Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in this feasibility study. All three participants tolerated well the NF training. Moreover, two participants, despite the chronicity of their symptoms, showed clinically meaningful improvements, while one participant showed a smaller symptom reduction. Examination of changes in resting-state functional connectivity patterns revealed a normalization of brain connectivity consistent with clinical improvement. These preliminary results support feasibility of this novel intervention for PTSD and indicate that larger, well-controlled studies of efficacy are warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza