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Necrotic cell death and suppression of T-cell immunity characterized acute liver failure due to drug-induced liver injury.
Kakisaka, Keisuke; Kataoka, Kojiro; Suzuki, Yuji; Okada, Yohei; Yoshida, Yuichi; Kuroda, Hidekatsu; Takikawa, Yasuhiro.
Afiliación
  • Kakisaka K; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan. Electronic address: keikaki@iwate-med.ac.jp.
  • Kataoka K; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
  • Suzuki Y; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
  • Okada Y; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
  • Yoshida Y; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
  • Kuroda H; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
  • Takikawa Y; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Japan.
Cytokine ; 86: 21-28, 2016 10.
Article en En | MEDLINE | ID: mdl-27442007
BACKGROUND & AIMS: The aim of this study was to investigate the clinical characteristics and pathophysiology of drug-induced liver injury (DILI) - acute liver failure (ALF). METHODS: The patients with acute liver injury (ALI) including ALF from 2009 to 2014 were analyzed. The hepatic encephalopathy (HE) development rate was compared with the findings from a national survey in Japan. The serum cytokines levels and the findings of a liver function test were evaluated in the DILI patients. RESULTS: The HE development rate substantially decreased for autoimmune hepatitis (AIH) - and undetermined cause-induced ALI owing to the early prediction system, but not in DILI-ALI. Among the DILI-ALF and AIH-ALF cases, the CK-18 fragment (1480.1U/L, 3945.4U/L), IL-8 (82.9pg/mL, 207.5pg/mL), IP-10 (1379.6pg/mL, 3731.2pg/mL) and MIP-1ß (1017.7pg/mL, 2273.3pg/mL) levels were lower in the DILI-ALF cases. Among the DILI-ALI and DILI-ALF cases, IL-4 (19.8pg/mL, 25.4pg/mL) and RANTES (14028.0pg/mL, 17804.7pg/mL) were higher in DILI-ALI, and HMGB-1 (397.1pg/µL, 326.2pg/µL) and HGF (2.41ng/mL, 0.55ng/mL) were higher in DILI-ALF. We observed that HGF independently associated with DLI-ALF development. CONCLUSIONS: Despite the low grade apoptosis and inflammation, DILI patients progressed to ALF comparable with that of the AIH patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Fallo Hepático Agudo / Enfermedad Hepática Inducida por Sustancias y Drogas / Hígado Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T / Fallo Hepático Agudo / Enfermedad Hepática Inducida por Sustancias y Drogas / Hígado Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido