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Genetic dissection of acetic acid tolerance in Saccharomyces cerevisiae.
Geng, Peng; Xiao, Yin; Hu, Yun; Sun, Haiye; Xue, Wei; Zhang, Liang; Shi, Gui-Yang.
Afiliación
  • Geng P; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.
  • Xiao Y; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.
  • Hu Y; The Key Laboratory of Industrial Biotechnology of Ministry of Education, Jiangnan University, Wuxi, China.
  • Sun H; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.
  • Xue W; School of Information Science and Technology, Nanjing Agricultural University, Nanjing, China.
  • Zhang L; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China. zhangl@jiangnan.edu.cn.
  • Shi GY; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, 1800 Lihu Road, Wuxi, 214122, China.
World J Microbiol Biotechnol ; 32(9): 145, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27430512
Dissection of the hereditary architecture underlying Saccharomyces cerevisiae tolerance to acetic acid is essential for ethanol fermentation. In this work, a genomics approach was used to dissect hereditary variations in acetic acid tolerance between two phenotypically different strains. A total of 160 segregants derived from these two strains were obtained. Phenotypic analysis indicated that the acetic acid tolerance displayed a normal distribution in these segregants, and suggested that the acetic acid tolerant traits were controlled by multiple quantitative trait loci (QTLs). Thus, 220 SSR markers covering the whole genome were used to detect QTLs of acetic acid tolerant traits. As a result, three QTLs were located on chromosomes 9, 12, and 16, respectively, which explained 38.8-65.9 % of the range of phenotypic variation. Furthermore, twelve genes of the candidates fell into the three QTL regions by integrating the QTL analysis with candidates of acetic acid tolerant genes. These results provided a novel avenue to obtain more robust strains.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Ácido Acético / Genómica / Sitios de Carácter Cuantitativo Idioma: En Revista: World J Microbiol Biotechnol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Ácido Acético / Genómica / Sitios de Carácter Cuantitativo Idioma: En Revista: World J Microbiol Biotechnol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania