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Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review.
Hsiao, S-H; Chang, H-J; Hsieh, T-H; Kao, S-M; Yeh, P-Y; Wu, T-J.
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  • Hsiao SH; Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan.
  • Chang HJ; Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan.
  • Hsieh TH; Department of Internal Medicine, Medical college and Hospital, National Cheng Kung University, Tainan, Taiwan.
  • Kao SM; Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan.
  • Yeh PY; Department of Pharmacy, National Cheng Kung University Hospital, Tainan, Taiwan.
  • Wu TJ; Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
J Clin Pharm Ther ; 41(5): 575-8, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27430348
WHAT IS KNOWN AND OBJECTIVE: Rhabdomyolysis is a severe potential adverse drug reaction of statin therapy. We report a case of rhabdomyolysis due to drug-drug interaction (DDI) between atorvastatin and fluconazole and review the literature. CASE SUMMARY: A 70-year-old woman received atorvastatin for hyperlipidaemia without any problem for 4 years. When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later. Removal of atorvastatin led to the resolution of her rhabdomyolysis. WHAT IS NEW AND CONCLUSION: Our case demonstrates that in some subjects even a moderate CYP3A4 inhibitor such as fluconazole may lead to rhabdomyolysis in subjects receiving a statin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabdomiólisis / Fluconazol / Inhibidores del Citocromo P-450 CYP3A / Atorvastatina Límite: Aged / Female / Humans Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Rabdomiólisis / Fluconazol / Inhibidores del Citocromo P-450 CYP3A / Atorvastatina Límite: Aged / Female / Humans Idioma: En Revista: J Clin Pharm Ther Asunto de la revista: FARMACIA / TERAPEUTICA Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido