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Success after failure: the role of endometrial stem cells in recurrent miscarriage.
Lucas, Emma S; Dyer, Nigel P; Fishwick, Katherine; Ott, Sascha; Brosens, Jan J.
Afiliación
  • Lucas ES; Division of Biomedical SciencesWarwick Medical School, Coventry, UK Tommy's National Centre for Miscarriage ResearchUniversity Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.
  • Dyer NP; Warwick Systems Biology CentreUniversity of Warwick, Coventry, UK.
  • Fishwick K; Division of Biomedical SciencesWarwick Medical School, Coventry, UK.
  • Ott S; Tommy's National Centre for Miscarriage ResearchUniversity Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK Warwick Systems Biology CentreUniversity of Warwick, Coventry, UK.
  • Brosens JJ; Division of Biomedical SciencesWarwick Medical School, Coventry, UK Tommy's National Centre for Miscarriage ResearchUniversity Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK J.J.Brosens@warwick.ac.uk.
Reproduction ; 152(5): R159-66, 2016 11.
Article en En | MEDLINE | ID: mdl-27430234
Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obligatory transformation process for embryo implantation. These novel findings should pave the way for more effective screening of women at risk of pregnancy failure before conception.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Regeneración / Aborto Habitual / Endometrio / Células Madre Mesenquimatosas Límite: Female / Humans / Pregnancy Idioma: En Revista: Reproduction Asunto de la revista: MEDICINA REPRODUTIVA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Regeneración / Aborto Habitual / Endometrio / Células Madre Mesenquimatosas Límite: Female / Humans / Pregnancy Idioma: En Revista: Reproduction Asunto de la revista: MEDICINA REPRODUTIVA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido