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Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer.
Pozza, Anna; Ruffolo, Cesare; Fiorot, Alain; Padoan, Luigi; Erroi, Francesca; Massani, Marco; Caratozzolo, Ezio; Bonariol, Luca; Ferrara, Francesco; Norberto, Lorenzo; Castoro, Carlo; Bassi, Nicolò; Scarpa, Marco.
Afiliación
  • Pozza A; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Ruffolo C; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Fiorot A; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Padoan L; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Erroi F; b Department of Surgical, Oncological and Gastroenterological Sciences , University of Padova , Padova , Italy.
  • Massani M; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Caratozzolo E; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Bonariol L; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Ferrara F; c Gastroenterology Unit , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Norberto L; b Department of Surgical, Oncological and Gastroenterological Sciences , University of Padova , Padova , Italy.
  • Castoro C; d Oncological Surgery Unit , Veneto Institute of Oncology (IOV-IRCCS) , Padova , Italy.
  • Bassi N; a II Department of Surgery (IV Unit) , Regional Hospital 'Cà Foncello' , Treviso , Italy.
  • Scarpa M; d Oncological Surgery Unit , Veneto Institute of Oncology (IOV-IRCCS) , Padova , Italy.
Acta Chir Belg ; 116(4): 225-230, 2016 Aug.
Article en En | MEDLINE | ID: mdl-27426670
BACKGROUND: The principal aim of endoscopic follow-up programs after curative resection of colorectal cancer (CRC) is to improve survival and identify local recurrence and metachronous CRC. The aim of our study was to identify the possible predictors of metachronous colorectal lesions. METHODS: The records of 348 consecutive patients with CRC and who completed at least 1 year of endoscopic follow-up after surgery were analyzed. In this group, 336 patients underwent surgery for primitive CRC and 12 for metachronous cancer. Patients' characteristics, operative details, and endoscopical follow-up findings were retrieved. Multivariate survival analyses were used to identify patient categories at risk of metachronous colonic lesions. RESULTS: 128 patients presented a metachronous lesion: 118 adenomas and 10 adenocarcinomas. At multivariate analysis, active smoke (HR = 1.84, p = 0.03), neoadjuvant therapy (HR = 0.24, p = 0.01), and presence of synchronous polyps (HR = 1.55, p = 0.04) resulted independent predictors of metachronous adenoma after CRC removal while neoadjuvant therapy (HR = 0.25, p = 0.02), active smoke (HR = 1.54, p = 0.04), and presence of synchronous polyps (HR = 1.86, p = 0.02) resulted independent predictors of metachronous lesions after CRC removal. CONCLUSIONS: This study demonstrated a high rate of metachronous lesions in the early follow-up after curative CRC resection. The negative effects of synchronous polyps should be carefully evaluated when planning patients' follow-up.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pólipos / Neoplasias Colorrectales / Adenocarcinoma / Neoplasias Primarias Secundarias / Neoplasias Primarias Múltiples Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Chir Belg Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Buscar en Google
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Imprimir
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pólipos / Neoplasias Colorrectales / Adenocarcinoma / Neoplasias Primarias Secundarias / Neoplasias Primarias Múltiples Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Chir Belg Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido