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Deep brain stimulation in the central nucleus of the amygdala decreases 'wanting' and 'liking' of food rewards.
Ross, Shani E; Lehmann Levin, Emily; Itoga, Christy A; Schoen, Chelsea B; Selmane, Romeissa; Aldridge, J Wayne.
Afiliación
  • Ross SE; Biomedical Engineering Department, Ann Arbor, MI, USA.
  • Lehmann Levin E; Department of Neurosurgery, Ann Arbor, MI, USA.
  • Itoga CA; Neuroscience Graduate Program, Ann Arbor, MI, USA.
  • Schoen CB; Department of Psychology, 530 Church Street, Ann Arbor, MI, 48109-1043, USA.
  • Selmane R; Department of Psychology, 530 Church Street, Ann Arbor, MI, 48109-1043, USA.
  • Aldridge JW; Department of Biology, University of Michigan, Ann Arbor, MI, USA.
Eur J Neurosci ; 44(7): 2431-2445, 2016 10.
Article en En | MEDLINE | ID: mdl-27422085
We investigated the potential of deep brain stimulation (DBS) in the central nucleus of the amygdala (CeA) in rats to modulate functional reward mechanisms. The CeA is the major output of the amygdala with direct connections to the hypothalamus and gustatory brainstem, and indirect connections with the nucleus accumbens. Further, the CeA has been shown to be involved in learning, emotional integration, reward processing, and regulation of feeding. We hypothesized that DBS, which is used to treat movement disorders and other brain dysfunctions, might block reward motivation. In rats performing a lever-pressing task to obtain sugar pellet rewards, we stimulated the CeA and control structures, and compared stimulation parameters. During CeA stimulation, animals stopped working for rewards and rejected freely available rewards. Taste reactivity testing during DBS exposed aversive reactions to normally liked sucrose tastes and even more aversive taste reactions to normally disliked quinine tastes. Interestingly, given the opportunity, animals implanted in the CeA would self-stimulate with 500 ms trains of stimulation at the same frequency and current parameters as continuous stimulation that would stop reward acquisition. Neural recordings during DBS showed that CeA neurons were still active and uncovered inhibitory-excitatory patterns after each stimulus pulse indicating possible entrainment of the neural firing with DBS. In summary, DBS modulation of CeA may effectively usurp normal neural activity patterns to create an 'information lesion' that not only decreased motivational 'wanting' of food rewards, but also blocked 'liking' of rewards.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Conducta Animal / Estimulación Encefálica Profunda / Núcleo Amigdalino Central / Preferencias Alimentarias / Motivación Límite: Animals Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Conducta Animal / Estimulación Encefálica Profunda / Núcleo Amigdalino Central / Preferencias Alimentarias / Motivación Límite: Animals Idioma: En Revista: Eur J Neurosci Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia